2­Diethylaminoethanol

IDLH Documentation

CAS number: 100­37­8

NIOSH REL: 10 ppm (50 mg/m3) TWA [skin]

Current OSHA PEL: 10 ppm (50 mg/m3) TWA [skin]

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 10 ppm (48 mg/m3) TWA [skin]

Description of Substance: Colorless liquid with a nauseating, ammonia­like odor.

LEL:. . Unknown

Original (SCP) IDLH: 500 ppm

Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for diethylaminoethanol. The chosen IDLH is based on the following statements by Cornish [1965]: "exposure of rats to 500 ppm, 6 hours daily for 5 days, resulted in severe weight loss and high mortality. Daily exposure at 200 ppm resulted in the death of 7 of 50 rats during the first month. A single human exposure for a few seconds to a level well below 200 ppm resulted in nausea and vomiting."

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:



Species


Reference
LC50

(ppm)
LCLo

(ppm)


Time
Adjusted 0.5-hr

LC (CF)
Derived

value
Rat

Mouse
Lomonova 1970

Lomonova 1970
924

1,027
-----

-----
4 hr

?
1,848 ppm (2.0)

?
185 ppm

?


Lethal dose data:


Species

Reference

Route
LD50

(mg/kg)
LDLo

(mg/kg)

Adjusted LD

Derived value
Rat
Smyth and Carpenter 1944
oral
1,300
-----
1,869 ppm
187 ppm


Human data: A very short exposure (<30 seconds) to a concentration estimated to be less than 100 ppm has resulted in nausea and vomiting within 5 minutes; other persons in the same room also complained of the nauseating odor but did not become ill [Cornish 1965].

Revised IDLH: 100 ppm

Basis for revised IDLH: The revised IDLH for 2­diethylaminoethanol is 100 ppm based on acute inhalation toxicity data in humans [Cornish 1965].


REFERENCES:

1. Cornish HH [1965]. Oral and inhalation toxicity of 2­diethylaminoethanol. Am Ind Hyg Assoc J 26:479­484.

2. Lomonova GV [1970]. Toxicology data on dimethylethanolamine and diethylethanolamine. Gig Tr Prof Zabol 14(11):52­53 (translated).

3. Smyth HF Jr, Carpenter CP [1944]. The place of the range­finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol 26:269­273.
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