Allyl glycidyl ether

CAS number . . . . . . . . . . . 106-92-3
NIOSH REL. . . . . . . . . . . . 5 ppm (22 mg/m3) TWA, 10 ppm (44 mg/m3) STEL
                                 [skin]
Current OSHA PEL . . . . . . . . 10 ppm (45 mg/m3) CEILING
1989 OSHA PEL. . . . . . . . . . 5 ppm (22 mg/m3) TWA, 10 ppm (44 mg/m3) STEL
1993-1994 ACGIH TLV. . . . . . . 5 ppm (23 mg/m3) TWA, 10 ppm (47 mg/m3) STEL
Description of substance . . . . Colorless liquid with a pleasant odor.
LEL. . . . . . . . . . . . . . . Unknown
Original (SCP) IDLH. . . . . . . 270 ppm
Basis for original (SCP) IDLH. . The chosen IDLH is based on the mouse 4-hour
                                 LC50 of 270 ppm [Hine et al. 1956] cited in
                                 ACGIH [1971], AIHA [1965], and Patty [1963].
Short-term exposure guidelines . None developed

ACUTE TOXICITY DATA

Lethal concentration data:

                                                       Adjusted               
                             LC50    LCLo               0.5-hr         Derived
Species     Reference       (ppm)   (ppm)    Time       LC (CF)         Value
______________________________________________________________________________
Mouse    Hine et al. 1956    270    -----    4 hr     540 ppm (2.0)     54 ppm
Rat      Hine et al. 1956    670    -----    8 hr   1,675 ppm (2.5)    168 ppm

                                  
Human data . . . . . . . . . . . None relevant for determining the revised
                                 IDLH.

Revised IDLH: 50 ppm
Basis for revised IDLH: The revised IDLH for allyl glycidyl ether is 50 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

REFERENCES:

1. ACGIH [1971]. Allyl glycidyl ether. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 9.
2. AIHA [1965]. Allyl glycidyl ether. In: Hygienic guide series. Am Ind Hyg Assoc J 26:89-91.
3. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.
4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1599.