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CAS number: 123864
NIOSH REL: 150 ppm (710 mg/m3) TWA, 200 ppm (950 mg/m3) STEL
Current OSHA PEL: 150 ppm (710 mg/m3) TWA
1989 OSHA PEL: 150 ppm (710 mg/m3) TWA, 200 ppm (950 mg/m3) STEL
19931994 ACGIH TLV: 150 ppm (713 mg/m3) TWA, 200 ppm (950 mg/m3) STEL
Description of Substance: Colorless liquid with a fruity odor.
LEL: . . 1.7% (10% LEL, 1,700 ppm)
Original (SCP) IDLH: 10,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that a 4hour exposure to 10,000 ppm killed no rats, but an 8hour exposure to 10,000 ppm killed all 6 rats [Smyth 1956].
Shortterm exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
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Food Cosmet Toxicol 1979
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| 18,866 ppm (1.34)
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Other animal data: A 4hour exposure to 10,000 ppm was not lethal to rats [Smyth 1956].
Human data: Severe irritation of the throat has been reported
in volunteers exposed to 300 ppm for 3 to 5 minutes
[Nelson et al. 1943]. However, it has also been reported that
irritation of the eyes and nose is first objectionable at 3,300 ppm
and that higher concentrations cause tearing and hyperemia of
the conjunctiva [Grant 1974].
| Revised IDLH: 1,700 ppm [LEL]
Basis for revised IDLH: Based on health considerations and acute inhalation toxicity data in humans [Grant 1974], a value of about 3,300 ppm would have been appropriate for nbutyl acetate. However, the revised IDLH for nbutyl acetate is 1,700 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 1.7%). |
REFERENCES:
1. ACGIH [1971]. nButyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 30.
2. EPA [1987]. TSCA section 8e submission and status report on nbutyl acetate. Washington, DC: U.S. Environmental Protection Agency, Office of Toxic Substances, Report No. 8EHQ03870659, April 6, 1987. [From ACGIH [1991]. nButyl acetate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 164165.]
3. Flury F, Wirth W [1933]. Zur toxikologie der losungsmittel (verschiedene ester, aceton, methylalkohol). Arch Gewerbepath Gewerbehyg 5:190 (in German).
4. Food Cosmet Toxicol [1979]; 17:515519.
5. Grant WM [1974]. Toxicology of the eye. 2nd ed. Springfield, IL: C.C. Thomas, pp. 210211.
6. Nelson KW, Ege JF, Ross M, Woodman LE, Silverman L [1943]. Sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 25(7):282285.
7. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 7.
8. Smyth HF Jr [1956]. Improved communication: hygienic standards for daily inhalation. Am Ind Hyg Assoc Q 17(2):129185.
9. UCC [1987]. nButyl acetate: acute vapor inhalation toxicity test in rats. Export, PA: Union Carbide Corporation, Bushy Run Research Center, Project Report No. 50135, November 17, 1987. [From ACGIH [1991]. nButyl acetate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 164165.]
10. Yakkyoku (Pharmacy) [1981]; 32(10):12411247 (in
Japanese).
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