n­Butyl glycidyl ether

IDLH Documentation

CAS number: 2426­08­6

NIOSH REL: 5.6 ppm (30 mg/m3) 15­minute CEILING

Current OSHA PEL: 50 ppm (270 mg/m3) TWA

1989 OSHA PEL: 25 ppm (135 mg/m3) TWA

1993­1994 ACGIH TLV: 25 ppm (133 mg/m3) TWA

Description of Substance: Colorless liquid with an irritating odor.

LEL: . . Unknown

Original (SCP) IDLH: 3,500 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that the mouse 4­hour LC50 was greater than 3,500 ppm [Hine et al. 1956].

Short­term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:


Species

Reference
LC50

(ppm)
LCLo

(ppm)

Time
Adjusted 0.5-hr

LC (CF)
Derived

value
Mouse

Rat
Hine et al. 1956

Hine et al. 1956
>3,500

1,030
-----

-----
4 hr

8 hr
>7,000 ppm (2.0)

2,575 ppm (2.5)
>700 ppm

258 ppm


Lethal dose data:


Species

Reference

Route
LD50

(mg/kg)
LDLo

(mg/kg)

Adjusted LD
Derived value
Mouse

Rat
Hine et al. 1956

Smyth et al. 1962
oral

oral
1,530

2,050
-----

-----
1,980 ppm

2,652 ppm
198 ppm

265 ppm


Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 250 ppm

Basis for revised IDLH: The revised IDLH for n­butyl glycidyl ether is 250 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.


REFERENCES:

1. ACGIH [1971]. n­Butyl glycidyl ether (BGE). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 33.

2. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250­264.

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range­finding toxicity data: list VI. Am Ind Hyg Assoc J 23:95­107.
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