Dieldrin

IDLH Documentation

CAS number: 60­57­1

NIOSH REL: 0.25 mg/m3 TWA [skin]; NIOSH considers dieldrin to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].

Current OSHA PEL: 0.25 mg/m3 TWA [skin]

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 0.25 mg/m3 TWA [skin]

Description of Substance: Colorless to light­tan crystals with a mild, chemical odor.

LEL:. . Noncombustible Solid

Original (SCP) IDLH: 450 mg/m3

Basis for original (SCP) IDLH: No data on acute inhalation toxicity are available on which to base the IDLH for dieldrin. The chosen IDLH, therefore, has been estimated from the statement by Deichmann and Gerarde [1969] that an oral dose of 65 mg/kg is believed to be a reasonable estimate of the lethal dose in man. Thienes and Haley [1972] and Gleason et al. [1969] reported similar estimates of the lethal dose for man [Hodge et al. 1967; Kalushner 1960].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:


Species

Reference

LC50

LCLo

Time
Adjusted 0.5-hr

LC (CF)
Derived

value
Cat

Rat
Gig Tr Prof Zabol 1964

Izmerov et al. 1982
80 mg/m3

13 mg/m3
-----

-----
4 hr

4 hr
160 mg/m3 (2.0)

26 mg/m3 (2.0)
16 mg/m3

2.6 mg/m3


Lethal dose data:


Species

Reference

Route
LD50

(mg/kg)
LDLo

(mg/kg)

Adjusted LD
Derived value
Rabbit

G. pig

Mouse

Dog

Rat
AAPCO 1966

AAPCO 1966

Kenaga and Morgan 1978

Spencer 1973

Treon and Cleveland 1955
oral

oral

oral

oral

oral
45

49

38

65

38
-----

-----

-----

-----

-----
315 mg/m3

343 mg/m3

266 mg/m3

455 mg/m3

266 mg/m3
32 mg/m3

34 mg/m3

27 mg/m3

46 mg/m3

27 mg/m3


Human data: The lethal oral dose has been estimated to be about 5 grams [Deichmann and Gerarde 1969; Hodge et al. 1967]. [Note: An oral dose of 5 grams is equivalent to a worker being exposed to 3,300 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

Revised IDLH: 50 mg/m3

Basis for revised IDLH: The revised IDLH for dieldrin is 50 mg/m3 based on acute oral toxicity data in humans [Deichmann and Gerarde 1969; Hodge et al. 1967]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for dieldrin at concentrations above 0.25 mg/m3.]


REFERENCES:

1. AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 377.

2. Deichmann WB, Gerarde HW [1969]. Dieldrin. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., pp. 215­216.

3. Gig Tr Prof Zabol [1964]; 8(4):30­34 (in Russian).

4. Gleason MN, Gosselin RE, Hodge HC, Smith RP [1969]. Clinical toxicology of commercial products. 3rd ed. Baltimore, MD: Williams & Wilkins Company, pp. 85­87.

5. Hodge HC, Boyce AM, Deichmann WB, Kraybill HF [1967]. Toxicology and no­effect levels of aldrin and dieldrin. Toxicol Appl Pharmacol 10:613­675.

6. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 73.

7. Kalushner A [1960]. Occupational dieldrin poisoning. JAMA 172(18):148­151.

8. Kenaga EE, Morgan RW [1978]. Commercial and experimental organic insecticides. Entomological Society of America Special Publication 78­1:13.

9. Spencer EY [1973]. Guide to the chemicals used in crop protection. 6th ed. London, Ontario, Canada: Research Institute, University of Western Ontario Sub Post Office, p. 13.

10. Thienes CH, Haley TJ [1972]. Clinical toxicology. 5th ed. Philadelphia, PA: Lea & Febiger, p. 26.

11. Treon JF, Cleveland FP [1955]. Toxicity of certain chlorinated hydrocarbon insecticides for laboratory animals. J Agri Food Chem 3:402­403.
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