CAS number: 64175
NIOSH REL: 1000 ppm (1,900 mg/m3) TWA
Current OSHA PEL: 1000 ppm (1,900 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 1000 ppm (1,880 mg/m3) TWA
Description of Substance: Clear, colorless liquid with a weak, ethereal, vinous odor.
LEL:. . 3.3% (10% LEL: 3,300 ppm)
Original (SCP) IDLH: 15,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH (15,000 ppm) is based on human inhalation data and is conservative. At 15,000 ppm "there was continuous lachrymation and coughing" in the exposed individuals [Lester and Greenberg 1951]. Further evidence of the IDLH being conservative is the report in Patty  that a 2hour exposure to 19,260 ppm only produced light narcosis in the rat; a 255minute exposure to 19,260 ppm produced no signs of intoxication in the guinea pig; a 75minute exposure to 23,940 ppm produced narcosis in the mouse; and a 80minute exposure to 13,300 ppm caused ataxia in the mouse.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
Lethal dose data:
Other animal data: RD50 (mouse), 27,314 ppm [Alarie 1981].
Human data: It was reported in a clinical study that concentrations greater than 20,900 ppm were intolerably irritating and 15,000 ppm caused continuous lacrimation and coughing while concentrations between 5,200 and 10,400 ppm allowed work to be carried on, but with a certain amount of discomfort [Lester and Greenberg 1951]. In this same study, it was determined that 62% of the ethyl alcohol inhaled was absorbed [Lester and Greenberg 1951].
|Revised IDLH: 3,300 ppm [LEL]
Basis for revised IDLH: Based on health considerations and acute inhalation toxicity data in humans [Lester and Greenberg 1951], a value of about 10,000 ppm would have been appropriate. However, the revised IDLH for ethyl alcohol is 3,300 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 3.3%).
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5. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1426.
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8. Wiberg GS, Trenhold HL, Coldwell BB . Increased ethanol
toxicity in old rats: changes in LD50, in vivo and in vitro metabolism,
and liver alcohol dehydrogenase activity. Toxicol Appl Pharmacol
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