NIOSH REL: 100 ppm (410 mg/m3) TWA
Current OSHA PEL: 100 ppm (410 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
19931994 ACGIH TLV: 100 ppm (410 mg/m3) TWA
Description of substance: Colorless liquid with an acrid, fruity odor.
LEL: . . . 1.7% (10% LEL, 1,700 ppm)
Original (SCP) IDLH: 4,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH  that 4,400 ppm was fatal to rats and rabbits in 8 hours [Deichmann 1941]. Also, Patty  cited an approximate rat LC50 of 3,750 ppm [Deichmann 1941; Spealman et al. 1945].
Shortterm exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Rat||Blagodatin et al. 1976|
|Mouse||Blagodatin et al. 1976|
|G. pig||Deichmann 1941|
|Mammal||Gig Sanit 1986|
Human data: Workers have experienced irritation, but tolerated
200 ppm without complaint [Spealman et al. 1945]. It has
also been reported that 2,300 ppm was intolerable [Coleman
|Revised IDLH: 1,000 ppm
Basis for revised IDLH: The revised IDLH for methyl methacrylate is 1,000 ppm based on acute inhalation toxicity data in humans [Coleman 1963] and animals [Blagodatin et al. 1976; Deichmann 1941].
1. ACGIH . Methyl methacrylate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 168.
2. Blagodatin VM, Smiznova ES, et al. . Substantiation of the maximum permissible concentration of methacrylic acid methyl ether in the air of the working zone. Gig Tr Prof Zabol 20(6):58 (in Russian).
3. Coleman AL . Letter to the TLV Committee from State of Connecticut, Labor Department, Occupational Health Section (March 15, 1963).
4. Deichmann W . Toxicity of methyl, ethyl, and nbutyl methacrylate. J Ind Hyg Toxicol 23:343351.
5. Gig Sanit ; 51(5):61 (in Russian).
6. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1880.
7. Spealman CR, Main RJ, Haag HB, Larson PS . Monomeric
methyl methacrylate. Am J Ind Med 14(4):292298.
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