International Chemical Safety Cards 4-CHLOROANILINE ICSC: 0026 Chloroaminobenzene, p- Chloroaniline, p- C6H6ClN / ClC6H4NH2 Molecular mass: 127.6 ICSC #    0026 CAS #     106-47-8 RTECS # BX0700000 UN #        2018 EC #         612-137-00-9 October 18, 2001 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION EXPOSURE PREVENT DISPERSION OF DUST! STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Blue lips or finger nails. Blue skin. Confusion. Convulsions. Dizziness. Headache. Nausea. Unconsciousness. Local exhaust or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN MAY BE ABSORBED! (Further see Inhalation). Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Redness. Pain. Safety goggles, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION (See Inhalation). Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: P3 filter respirator for toxic particles.) Chemical protection suit. Do NOT let this chemical enter the environment. Separated from strong oxidants, food and feedstuffs . Do not transport with food and feedstuffs. Note: E T symbol N symbol R: 45-23/24/25-43-50/53 S: 53-45-60-61 UN Hazard Class: 6.1 UN Packing Group: II SEE IMPORTANT INFORMATION ON BACK ICSC: 0026 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards 4-CHLOROANILINE ICSC: 0026 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS TO YELLOW CRYSTALS , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on burning producing toxic and corrosive fumes including hydrogen chloride , nitrogen oxides . Reacts violently with oxidants. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. MAK: 2 H (DFG 2000). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. INHALATION RISK: A harmful concentration of airborne particles can be reached quickly when dispersed. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes . The substance may cause effects on the red blood cells , resulting in lesions of blood cells and formation of methaemoglobin. Medical observation is indicated. The effects may be delayed. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the spleen. Tumours have been detected in experimental animals but may not be relevant to humans (see Notes). PHYSICAL PROPERTIES Boiling point: 232°C Melting point: 69-72.5°C Relative density (water = 1): 1.4 Solubility in water, g/100 ml at 20°C: 0.39 Vapour pressure, Pa at 20°C: 2 Relative vapour density (air = 1): 4.4 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 120-123°C o.c. Auto-ignition temperature: 685°C Octanol/water partition coefficient as log Pow: 1.8 ENVIRONMENTAL DATA The substance is toxic to aquatic organisms. It is strongly advised that this substance does not enter the environment. N O T E S Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Transport Emergency Card: TEC (R)-61S2018 ADDITIONAL INFORMATION ICSC: 0026 4-CHLOROANILINE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.