International Chemical Safety Cards ISOPHORONE ICSC: 0169 1,1,3-Trimethyl-3-cyclohexene-5-one 3,5,5-Trimethylcyclohex-2-enone Isoacetophorone C9H14O Molecular mass: 138.2 ICSC #    0169 CAS #     78-59-1 RTECS # GW7700000 EC #         606-012-00-8 April 10, 2000 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION Above 84°C explosive vapour/air mixtures may be formed. Above 84°C use a closed system, ventilation. EXPOSURE PREVENT GENERATION OF MISTS!  •INHALATION Burning sensation. Sore throat. Cough. Dizziness. Headache. Nausea. Shortness of breath. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.  •SKIN Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.  •EYES Redness. Pain. Blurred vision. Safety spectacles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Abdominal pain. (Further see Inhalation). Do not eat, drink, or smoke during work. Rinse mouth. Give a slurry of activated charcoal in water to drink. Do NOT induce vomiting. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: filter respirator for organic gases and vapours. Separated from strong oxidants, strong bases, amines . Xn symbol R: 21/22-36/37-40 S: 2-13-23-36/37/39-46 SEE IMPORTANT INFORMATION ON BACK ICSC: 0169 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards ISOPHORONE ICSC: 0169 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: CHEMICAL DANGERS: Reacts with strong oxidants, strong bases and amines. OCCUPATIONAL EXPOSURE LIMITS: TLV: 5 ppm; (Ceiling value); A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2004). MAK: 2 ppm, 11 mg/m³; Peak limitation category: I(2); Carcinogen category: 3B; Pregnancy risk group: C; (DFG 2004). OSHA PEL: TWA 25 ppm (140 mg/m3) NIOSH REL: TWA 4 ppm (23 mg/m3) NIOSH IDLH: 200 ppm ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. INHALATION RISK: A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance and the vapour of this substance is irritating to the eyes and the respiratory tract . The substance may cause effects on the central nervous system . EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Boiling point: 215°C Melting point: -8°C Relative density (water = 1): 0.92 Solubility in water, g/100 ml at 25°C: 1.2 Vapour pressure, Pa at 20°C: 40 Relative vapour density (air = 1): 4.8 Flash point: 84°C c.c. Auto-ignition temperature: 460°C Explosive limits, vol% in air: 0.8-3.8 Octanol/water partition coefficient as log Pow: 1.67 ENVIRONMENTAL DATA N O T E S The occupational exposure limit value should not be exceeded during any part of the working exposure. Card has been partly updated in April 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response. NFPA Code: H 2; F 2; R 0; ADDITIONAL INFORMATION ICSC: 0169 ISOPHORONE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.