International Chemical Safety Cards

PHOSPHAMIDON

ICSC: 0189

2-Chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate
2-Chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl phosphate
Dimethyl phosphate ester 2-chloro-N,N-diethyl-3-hydroxycrotonamide
O,O-Dimethyl-O-(2-chloro-2-diethylcarbamoyl-1-methylvinyl) phosphate
C₁₀H₁₉ClNO₅P
Molecular mass: 299.7

ICSC #    0189
CAS #     13171-21-6
RTECS # TC2800000
UN #        3018
EC #         015-022-00-6
March 13, 1995 Peer reviewed

TYPES OF HAZARD/ EXPOSURE	ACUTE HAZARDS/ SYMPTOMS	PREVENTION	FIRST AID/ FIRE FIGHTING
FIRE	Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.		In case of fire in the surroundings: alcohol-resistant foam, powder, carbon dioxide.
EXPLOSION

EXPOSURE		STRICT HYGIENE!
•INHALATION	Dizziness. Sweating. Laboured breathing. Unconsciousness. Vomiting. Pupillary constriction, muscle cramp, excessive salivation. Symptoms may be delayed (see Notes).	Ventilation, local exhaust, or breathing protection.	Fresh air, rest. Artificial respiration if indicated. Refer for medical attention.
•SKIN	MAY BE ABSORBED! (Further see Inhalation).	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
•EYES	Redness. Pain.	Face shield, or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION	Abdominal cramps. Diarrhoea. Nausea. Vomiting. Pupillary constriction, muscle cramps, excessive salivation. (Further see Inhalation).	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. (Extra personal protection: complete protective clothing including self-contained breathing apparatus).

Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room.

Do not transport with food and feedstuffs.
Severe marine pollutant.
T+ symbol
R: 24-28-40
S: 1/2-23-36/37-45
UN Hazard Class: 6.1
UN Packing Group: II

SEE IMPORTANT INFORMATION ON BACK

ICSC: 0189

Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

PHOSPHAMIDON

ICSC: 0189

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PHYSICAL STATE; APPEARANCE:
COLOURLESS TO YELLOW LIQUID.

PHYSICAL DANGERS:

CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing highly toxic fumes including phosphorous oxides, hydrogen chloride and nitrogen oxides. Reacts with bases (hydrolysis). Attacks metals such as iron, tin and aluminium.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.

ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance irritates the eyes. The substance may cause effects on the nervous system , resulting in convulsions, respiratory failure and death. Cholinesterase inhibitor. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms. May cause genetic damage in humans.

PHYSICAL
PROPERTIES

Boiling point at 0.2 kPa: 162°C
Relative density (water = 1): 1.21
Solubility in water: miscible

Vapour pressure, Pa at 20°C: 0.0033
Octanol/water partition coefficient as log Pow: 0.8

ENVIRONMENTAL
DATA

This substance may be hazardous to the environment; special attention should be given to aquatic organisms, birds and honey bees.

N O T E S

Depending on the degree of exposure, periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Commercial product is a mixture of isomers. Carrier solvents used in commercial formulations may change physical and toxicological properties. Do NOT take working clothes home. Dimecron, Phosron, Pillarcron, Apamidon, Dixon and Dimenox are trade names.

ADDITIONAL INFORMATION

ICSC: 0189	PHOSPHAMIDON
(C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE:

Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.