International Chemical Safety Cards HALOTHANE ICSC: 0277 2-Bromo-2-chloro-1,1,1-trifluoroethane 1-Bromo-1-chloro-2,2,2-trifluoroethane BrClHC2F3 Molecular mass: 197.4 ICSC #    0277 CAS #     151-67-7 RTECS # KH6550000 November 27, 2003 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. In case of fire in the surroundings: use appropriate extinguishing media. EXPLOSION In case of fire: keep drums, etc., cool by spraying with water. EXPOSURE STRICT HYGIENE! AVOID EXPOSURE OF (PREGNANT) WOMEN!  •INHALATION Confusion. Dizziness. Drowsiness. Nausea. Unconsciousness. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN Dry skin. Roughness. Protective gloves. Remove contaminated clothes. Rinse skin with plenty of water or shower.  •EYES Redness. Pain. Safety goggles, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION (See Inhalation). Do not eat, drink, or smoke during work. Rinse mouth. Do NOT induce vomiting. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. (Extra personal protection: self-contained breathing apparatus). Keep in the dark. Ventilation along the floor. R: S: SEE IMPORTANT INFORMATION ON BACK ICSC: 0277 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards HALOTHANE ICSC: 0277 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: HIGHLY VOLATILE COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: The vapour is heavier than air. CHEMICAL DANGERS: The substance decomposes on heating producing toxic and corrosive fumes including hydrogen bromide , hydrogen chloride , hydrogen fluoride . The substance decomposes under the influence of light . OCCUPATIONAL EXPOSURE LIMITS: TLV: 50 ppm; A4; (ACGIH 2003). MAK: 5 ppm, 41 mg/m³; Peak limitation category: II(8); Pregnancy risk group: B; (DFG 2002). OSHA PEL: none NIOSH REL: C 2 ppm (16.2 mg/m3) 60-minute *Note: REL for exposure to waste anesthetic gas. NIOSH IDLH: No data ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its vapour and by ingestion. INHALATION RISK: A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes . The substance may cause effects on the central nervous system and cardiovascular system . Exposure at high levels may result in unconsciousness. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The liquid defats the skin. The substance may have effects on the liver , resulting in liver impairment . Animal tests show that this substance possibly causes toxicity to human reproduction or development. PHYSICAL PROPERTIES Boiling point: 50°C Melting point: -118°C Relative density (water = 1): 1.87 Solubility in water, g/100 ml: 0.45 Vapour pressure, kPa at 20°C: 32.4 Relative vapour density (air = 1): 2.87 Relative density of the vapour/air-mixture at 20°C (air = 1): 2.9 Octanol/water partition coefficient as log Pow: 2.30 ENVIRONMENTAL DATA N O T E S 0.01% Thymol is used as a stabilizer. Fluothane is a trade name. High concentrations in the air cause a deficiency of oxygen with the risk of unconsciousness or death. Check oxygen content before entering area. ADDITIONAL INFORMATION ICSC: 0277 HALOTHANE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.