International Chemical Safety Cards gamma-BUTYROLACTONE ICSC: 1020 1,4-Butanolide Butyric acid lactone Tetrahydro-2-furanone Dihydro-2(3H)-furanone C4H6O2 Molecular mass: 86.1 ICSC #    1020 CAS #     96-48-0 RTECS # LU3500000 October 03, 2000 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. NO open flames. Powder, alcohol-resistant foam, water spray, carbon dioxide. EXPLOSION EXPOSURE  •INHALATION Ventilation. Fresh air, rest.  •SKIN Protective gloves. Rinse skin with plenty of water or shower.  •EYES Redness. Pain. Safety spectacles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Vomiting. Drowsiness. Laboured breathing. Unconsciousness. Do not eat, drink, or smoke during work. Rinse mouth. Rest. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. (Extra personal protection: filter respirator for organic gases and vapours). Separated from acids, alcohols , amines and bases . Dry. R: S: SEE IMPORTANT INFORMATION ON BACK ICSC: 1020 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards gamma-BUTYROLACTONE ICSC: 1020 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS , OILY , HYGROSCOPIC LIQUID . PHYSICAL DANGERS: CHEMICAL DANGERS: Reacts with acids , bases , alcohols and amines . The substance decomposes on burning producing irritating fumes . OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its vapour and by ingestion . INHALATION RISK: No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance irritates the eyes . The substance may cause effects on the central nervous system , resulting in respiratory failure when ingested. Exposure could cause lowering of consciousness. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Boiling point: 204°C Melting point: -44°C Relative density (water = 1): 1.1 Solubility in water: miscible Vapour pressure, kPa at 20°C: 0.15 Relative vapour density (air = 1): 3.0 Flash point: 98°C c.c. Auto-ignition temperature: 455°C Explosive limits, vol% in air: 0.3-16.0 Octanol/water partition coefficient as log Pow: -0.57 ENVIRONMENTAL DATA N O T E S Use of alcoholic beverages enhances the harmful effect. NFPA Code: H0; F1; R0; ADDITIONAL INFORMATION ICSC: 1020 gamma-BUTYROLACTONE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.