International Chemical Safety Cards COUMARIN ICSC: 1105 1,2-Benzopyrone 2H-1-Benzopyran-2-one C9H6O2 Molecular mass: 146.14 ICSC #    1105 CAS #     91-64-5 RTECS # GN4200000 UN #        2811 March 27, 1998 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. NO open flames. Water spray, foam, powder, carbon dioxide. EXPLOSION EXPOSURE PREVENT DISPERSION OF DUST!  •INHALATION Ventilation. Fresh air, rest.  •SKIN MAY BE ABSORBED! Redness. Pain. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap.  •EYES Face shield. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Carefully collect remainder, then remove to safe place. (Extra personal protection: P2 filter respirator for harmful particles). Separated from food and feedstuffs. Do not transport with food and feedstuffs. R: S: UN Hazard Class: 6.1 UN Packing Group: I,II,III SEE IMPORTANT INFORMATION ON BACK ICSC: 1105 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards COUMARIN ICSC: 1105 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS FLAKES , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: CHEMICAL DANGERS: OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly. EFFECTS OF SHORT-TERM EXPOSURE: The substance irritates the skin . EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: This substance is possibly carcinogenic to humans. PHYSICAL PROPERTIES Boiling point: 297-299°C Melting point: 68-70°C Density: 0.94 g/cm3 Solubility in water: poor Vapour pressure, kPa at 106°C: 0.13 Flash point: 150°C Octanol/water partition coefficient as log Pow: 1.39 ENVIRONMENTAL DATA N O T E S Transport Emergency Card: TEC (R)-61G12c ADDITIONAL INFORMATION ICSC: 1105 COUMARIN (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.