International Chemical Safety Cards TOLUENE-2,6-DIISOCYANATE ICSC: 1301 2,6-Diisocyanatotoluene 2,6-Diisocyanato-1-methylbenzene Tolylene 2,6-diisocyanate 2,6-TDI C9H6N2O2 / CH3C6H3(NCO)2 Molecular mass: 174.2 ICSC #    1301 CAS #     91-08-7 RTECS # CZ6310000 UN #        2078 EC #         615-006-00-4 November 27, 1998 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, alcohol-resistant foam, water spray, carbon dioxide. EXPLOSION In case of fire: cool drums, etc., by spraying with water but avoid contact of the substance with water. EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Abdominal pain. Cough. Nausea. Shortness of breath. Sore throat. Vomiting. Symptoms may be delayed (see Notes). Ventilation, local exhaust, or breathing protection. Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.  •SKIN Redness. Burning sensation. Pain. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Redness. Pain. Blurred vision. Face shield or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Diarrhoea. (Further see Inhalation). Do not eat, drink, or smoke during work. Rinse mouth. Give plenty of water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Evacuate danger area! Consult an expert! Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. Personal protection: complete protective clothing including self-contained breathing apparatus. Separated from food and feedstuffs . See Chemical Dangers. Cool. Dry. Keep in a well-ventilated room. Do not transport with food and feedstuffs. Note: C T+ symbol R: 26-36/37/38-40-42/43-52/53 S: 1/2-23-36/37-45-61 UN Hazard Class: 6.1 UN Packing Group: II SEE IMPORTANT INFORMATION ON BACK ICSC: 1301 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards TOLUENE-2,6-DIISOCYANATE ICSC: 1301 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS TO YELLOW LIQUID , WITH PUNGENT ODOUR. TURNS TO PALE YELLOW ON EXPOSURE TO AIR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance may polymerize under the influence of water , acid(s) , base(s) or heat with fire or explosion hazard. The substance decomposes on burning producing toxic fumesincluding nitrogen oxides and cyanides. Reacts violently with alcohols amines and bases . Attacks many plastics, rubber, aluminium, copper and zinc. OCCUPATIONAL EXPOSURE LIMITS: TLV: 0.005 ppm as TWA; 0.02 ppm as STEL; A4 (not classifiable as a human carcinogen); SEN (ACGIH 2004). MAK: sensitization of respiratory tract (Sa); Carcinogen category: 3A; (DFG 2004). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its vapour and by ingestion. INHALATION RISK: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes , the skin and the respiratory tract . Inhalation of vapour may cause asthma-like reactions. Inhalation of vapour may cause chemical bronchitis, pneumonitis and lung oedema. Exposure far above the OEL may result in death. The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma. This substance is possibly carcinogenic to humans. PHYSICAL PROPERTIES Boiling point at 2.4kPa: 129-133°C Relative density (water = 1): 1.2 Solubility in water: reaction Vapour pressure, Pa at 20°C: about 2 Relative vapour density (air = 1): 6 Flash point: 127°C Auto-ignition temperature: 620°C Explosive limits, vol% in air: 0.9-9.5 ENVIRONMENTAL DATA N O T E S Technical toluene diisocyanate is a mixture of 2,4- and 2,6-isomers (mostly 80:20). Depending on the degree of exposure, periodic medical examination is suggested. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation is therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. No odour warning if toxic concentrations are present. See also ICSC0339 2,4-Toluene diisocyanate. Card has been partly updated in April 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response. Transport Emergency Card: TEC (R)-61S2078 or 61GT1-II NFPA Code: H3; F1; R3; ADDITIONAL INFORMATION ICSC: 1301 TOLUENE-2,6-DIISOCYANATE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.