International Chemical Safety Cards SEVOFLURANE ICSC: 1436 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane Ether, fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl- C4H3F7O Molecular mass: 200.1 ICSC #    1436 CAS #     28523-86-6 RTECS # KO0737000 March 05, 2002 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. In case of fire in the surroundings: use appropriate extinguishing media. EXPLOSION EXPOSURE  •INHALATION Dizziness. Drowsiness. Headache. Unconsciousness. See Notes. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.  •SKIN Dry skin. Redness. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.  •EYES Redness. Pain. Safety spectacles, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION (See Inhalation). Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking liquid in sealable containers. Ventilation. Absorb remaining liquid in sand or inert absorbent and remove to safe place. (Extra personal protection: self-contained breathing apparatus.) Ventilation along the floor. R: S: SEE IMPORTANT INFORMATION ON BACK ICSC: 1436 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards SEVOFLURANE ICSC: 1436 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS LIQUID PHYSICAL DANGERS: The vapour is heavier than air and may accumulate in lowered spaces causing a deficiency of oxygen. CHEMICAL DANGERS: On contact with hot surfaces or flames this substance decomposes forming corrosive fumes such as hydrogen chloride andhydrogen fluoride. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its vapour and by ingestion. INHALATION RISK: A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes and the skin . The substance may cause effects on the central nervous system and cardiovascular system . Exposure at high levels may result in unconsciousness. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Boiling point: 58.5°C Vapour pressure, kPa at 20°C: 21 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.1 Octanol/water partition coefficient as log Pow: 1.75 ENVIRONMENTAL DATA N O T E S Sevorane is a trade name. Check oxygen content before entering area. High concentrations in the air cause a deficiency of oxygen with the risk of unconsciousness or death. ADDITIONAL INFORMATION ICSC: 1436 SEVOFLURANE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.