NIOSH Pocket Guide to Chemical Hazards

Dimethyl acetamide

CAS 127-19-5


RTECS AB7700000
Synonyms & Trade Names
N,N-Dimethyl acetamide; DMAC
DOT ID & Guide


NIOSH REL: TWA 10 ppm (35 mg/m3) [skin]
OSHA PEL: TWA 10 ppm (35 mg/m3) [skin]
IDLH 300 ppm See: 127195 Conversion 1 ppm = 3.56 mg/m3
Physical Description
Colorless liquid with a weak, ammonia- or fish-like odor.
MW: 87.1
BP: 329°F
FRZ: -4°F
Sol: Miscible
VP: 2 mmHg
IP: 8.81 eV

Sp.Gr: 0.94
Fl.P(oc): 158°F
UEL(320°F): 11.5%
LEL(212°F): 1.8%

Class IIIA Combustible Liquid: Fl.P. at or above 140F and below 200F.
Incompatibilities & Reactivities
Carbon tetrachloride, other halogenated compounds when in contact with iron, oxidizers
Measurement Methods
NIOSH 2004
See: NMAM or OSHA Methods
Personal Protection & Sanitation (See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet or contaminated
Change: No recommendation
Provide: Quick drench
First Aid (See procedures)
Eye: Irrigate immediately
Skin: Water flush immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Important additional information about respirator selection
Respirator Recommendations NIOSH/OSHA
Up to 100 ppm:
(APF = 10) Any supplied-air respirator
Up to 250 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode
Up to 300 ppm:
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Irritation skin; jaundice, liver damage; depression, drowsiness, hallucinations, delusions
Target Organs Skin, liver, central nervous system
See also: INTRODUCTION   See ICSC CARD: 0259   See MEDICAL TESTS: 0080