NIOSH Pocket Guide to Chemical Hazards

Isopropyl acetate

CAS 108-21-4


RTECS AI4930000
Synonyms & Trade Names
Isopropyl ester of acetic acid, 1-Methylethyl ester of acetic acid, 2-Propyl acetate
DOT ID & Guide
1220 129


NIOSH REL: See Appendix D
OSHA PEL: TWA 250 ppm (950 mg/m3)
IDLH 1800 ppm See: 108214 Conversion 1 ppm = 4.18 mg/m3
Physical Description
Colorless liquid with a fruity odor.
MW: 102.2
BP: 194°F
FRZ: -92°F
Sol: 3%
VP: 42 mmHg
IP: 9.95 eV

Sp.Gr: 0.87
Fl.P: 36°F
UEL: 8%
LEL(100°F): 1.8%

Class IB Flammable Liquid: Fl.P. below 73F and BP at or above 100F.
Incompatibilities & Reactivities
Nitrates; strong oxidizers, alkalis & acids
Measurement Methods
NIOSH 1454, 1460; OSHA 7
See: NMAM or OSHA Methods
Personal Protection & Sanitation (See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet (flammable)
Change: No recommendation

First Aid (See procedures)
Eye: Irrigate immediately
Skin: Water flush promptly
Breathing: Respiratory support
Swallow: Medical attention immediately
Important additional information about respirator selection
Respirator Recommendations OSHA
Up to 1800 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin, nose; dermatitis; in animals: narcosis
Target Organs Eyes, skin, respiratory system, central nervous system
See also: INTRODUCTION   See ICSC CARD: 0907