NIOSH Pocket Guide to Chemical Hazards

Piperazine dihydrochloride

CAS 142-64-3

C4H10N2 • 2HCl

RTECS TL4025000
Synonyms & Trade Names
Piperazine hydrochloride [Note: The monochloride, C4H10N2 HCl, is also commercially available.]
DOT ID & Guide


NIOSH REL: TWA 5 mg/m3
OSHA PEL†: none
IDLH N.D. See: IDLH INDEX Conversion
Physical Description
White to cream-colored needles or powder.
MW: 159.1
BP: ?
MLT: 635°F
Sol: 41%
VP: ?
IP: ?

Sp.Gr: ?
Fl.P: ?
UEL: ?
LEL: ?

Combustible Solid, but does not ignite easily.
Incompatibilities & Reactivities
Water [Note: Slightly hygroscopic (i.e., absorbs moisture from the air).]
Measurement Methods
None available
See: NMAM or OSHA Methods
Personal Protection & Sanitation (See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet or contaminated
Change: Daily
Provide: Eyewash, Quick drench
First Aid (See procedures)
Eye: Irrigate immediately
Skin: Water flush immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Important additional information about respirator selection
Respirator Recommendations Not available.
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin, respiratory system; skin burns, sensitization; asthma; gastrointestinal upset, headache, nausea, vomiting, incoordination, muscle weakness
Target Organs Eyes, skin, respiratory system, central nervous system