NIOSH Pocket Guide to Chemical Hazards


CAS 25376-45-8
95-80-7 (2,4-TDA)


RTECS XS9445000
XS9625000 (2,4-TDA)
Synonyms & Trade Names
Diaminotoluene, Methylphenylene diamine, TDA, Toluenediamine isomers, Tolylenediamine [Note: Various isomers of TDA exist.]
DOT ID & Guide
1709 151 (2,4-Toluenediamine)


NIOSH REL: Ca (all isomers) See Appendix A
OSHA PEL: none
IDLH Ca [N.D.] See: IDLH INDEX Conversion
Physical Description
Colorless to brown, needle-shaped crystals or powder. [Note: Tends to darken on storage & exposure to air. Properties given are for 2,4-TDA.]
MW: 122.2
BP: 558°F
MLT: 210°F
Sol: Soluble
VP(224°F): 1 mmHg
IP: ?

Sp.Gr: 1.05 (Liquid at 212°F)
Fl.P: 300°F
UEL: ?
LEL: ?

Combustible Solid
Incompatibilities & Reactivities
None reported
Measurement Methods
NIOSH 5516; OSHA 65
See: NMAM or OSHA Methods
Personal Protection & Sanitation (See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated/Daily
Remove: When wet or contaminated
Change: Daily
Provide: Eyewash, Quick drench
First Aid (See procedures)
Eye: Irrigate immediately
Skin: Water flush immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Important additional information about respirator selection
Respirator Recommendations NIOSH
At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin, nose, throat; dermatitis; ataxia, tachycardia, nausea, vomiting, convulsions, respiratory depression; methemoglobinemia, cyanosis, headache, lassitude (weakness, exhaustion), dizziness, bluish skin; liver injury; [potential occupational carcinogen]
Target Organs Eyes, skin, respiratory system, blood, cardiovascular system, liver

Cancer Site [in animals: liver, skin & mammary gland tumors]