The Registry of Toxic Effects of Chemical Substances

Acetic acid, tert - butyl ester

RTECS #: AF7400000

CAS #: 540-88-5

UPDATE: November 2004 MW: 116.18 MF: C6H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethyl acetate
  2. Acetic acid, 1,1 - dimethylethyl ester (9CI)
  3. TLA
  4. Texaco lead appreciator
  1. t - Butyl acetate
  2. tert - Butyl acetate
  3. tert - Butyl acetate (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL mild NTIS** OTS0573684-1
skin
rabbit 		500 µL/24 hour mild NTIS** OTS0573684-1


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >2,230 mg/m3/4 hour N/R NTIS** OTS0573684-1
oral
rat 		lethal dose (50 percent kill): 4,100 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0573684-1
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Other changes 		NTIS** OTS0573684-1


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (950 mg/m3) DTLVS* 3,31,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (950 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (950 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (950 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (950 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 150 ppm (700 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 150 ppm (710 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (950 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 200 ppm (950 mg/m3), JAN1999
Occupational Exposure Limit - INDIA time-weighted average 200 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 950 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 900 mg/m3, MAC(short term exposure limit) 900 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 100 ppm (500 mg/m3), KTV 150 ppm (700 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (950 mg/m3), KZG- week 400 ppm (1900 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (966 mg/m3), short term exposure limit 250 ppm (1210 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 200 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 200 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO t-BUTYL ACETATE-air 10 hour time-weighted average 200 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Primary Irritant

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