The Registry of Toxic Effects of Chemical Substances

Acetic acid, mercury (2+) salt

RTECS #: AI8575000

CAS #: 1600-27-7

UPDATE: May 2004 MW: 318.69 MF: C4H6O4•Hg


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Bis (acetyloxy) mercury
  2. Diacetoxymercury
  3. Mercuriacetate
  4. Mercuric acetate
  5. Mercuric diacetate
  1. Mercury (2+) acetate
  2. Mercury (II) acetate
  3. Mercury diacetate
  4. Mercuryl acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in mammalian somatic cells hamster ovary 100 nmol/L EMMUEG 27,30,1996
other mutation test systems mouse other cell types 50 mg/L MUREAV 17,93,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
hamster 		lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities 		ENVRAL 8,207,1974
intravenous
hamster 		lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Homeostasis 		LSBGAY 10,1341,1971
intravenous
hamster 		lowest published toxic dose: 4 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ENVRAL 6,95,1973
intravenous
hamster 		lowest published toxic dose: 4 mg/kg (8 day pregnant) Reproductive: Other developmental abnormalities ENVRAL 8,207,1974
intravenous
rat 		lowest published toxic dose: 3 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ATSUDG 7,382,1984
oral
hamster 		lowest published toxic dose: 8 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ENVRAL 8,207,1974
oral
hamster 		lowest published toxic dose: 25 mg/kg (8 day pregnant) Reproductive: Other developmental abnormalities ENVRAL 8,207,1974
oral
hamster 		lowest published toxic dose: 35 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		ENVRAL 8,207,1974
oral
hamster 		lowest published toxic dose: 50 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Homeostasis ENVRAL 8,207,1974
subcutaneous
hamster 		lowest published toxic dose: 8 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Body wall 		ENVRAL 8,207,1974
subcutaneous
hamster 		lowest published toxic dose: 8 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Homeostasis ENVRAL 8,207,1974
subcutaneous
hamster 		lowest published toxic dose: 4 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ENVRAL 8,207,1974
subcutaneous
hamster 		lowest published toxic dose: 15 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		BECTA6 25,726,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 6,500 µg/kg N/R GTPZAB 25(7),27,1981
intravenous
mouse 		lethal dose (50 percent kill): 4,390 µg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		NYKZAU 57,219,1961
oral
mouse 		lethal dose (50 percent kill): 23,900 µg/kg N/R GISAAA 46(8),12,1981
oral
rat 		lethal dose (50 percent kill): 40,900 µg/kg N/R GISAAA 46(8),12,1981
subcutaneous
mouse 		lowest published lethal dose: 20 mg/kg N/R MOLAAF 73,751,1939
skin
rat 		lethal dose (50 percent kill): 570 mg/kg N/R GTPZAB 25(7),27,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 4,246 mg/kg/1 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) AMIHBC 2,433,1950


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01; short term exposure limit 0.03 mg/m3 (skin) DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 58,239,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 58,239,1993
TOXICOLOGY REVIEW
AJOGAH 126,390,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 mg(Hg)/m3 DTLWS* 3,22,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(Hg)/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg(Hg)/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.05 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 0.1 mg(Hg)/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.01 ppm (0.1 mg(Hg)/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.02 mg(Hg)/m3, short term exposure limit 0.04 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.05 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg(Hg)/m3, MAC(short term exposure limit) 0.15 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 mg(Hg)/m3, short term exposure limit 0.01 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.05 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - THAILAND short term exposure limit 0.05 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.025 mg(Hg)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.01;
short term exposure limit 0.03 mg/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.01;
short term exposure limit 0.03 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MERCURY, ARYL AND INORGANIC-air ceiling concentration 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83751;
Number of Industries 4;
Total Number of Facilities 109;
Number of Occupations 4;
Total Number of Employees Exposed 856
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83751;
Number of Industries 11;
Total Number of Facilities 320;
Number of Occupations 10;
Total Number of Employees Exposed 6,064;
Total Number of Female Employees Exposed 2,770


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
LSBGAY Life Sciences, Part 2: Biochemistry, General and Molecular Biology. (New York, NY) V.9-13, 1970-73. For publisher information, see LIFSAK.
MOLAAF Monatsschrift fuer Ohrenheilkunde und Laryngo-Rhinologie. (Vienna, Austria) V.1-108, 1867-1974. For publisher information, see LROTDW.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 6129-23-3
ALT CAS #: 7619-62-7
ALT CAS #: 19701-15-6
Click Here for Additional Information about RTECS