The Registry of Toxic Effects of Chemical Substances

Acetic acid, 2 - methoxy - 1 - methylethyl ester

RTECS #: AI8925000

CAS #: 108-65-6

UPDATE: November 2004 MW: 132.18 MF: C6H12O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1 - Methoxy - 2 - acetoxypropane
  2. 1 - Methoxy - 2 - propyl acetate
  3. 2 - Propanol, 1 - methoxy - , acetate (9CI)
  4. Dowanol (R) PMA glycol ether acetate
  1. PGMEA
  2. Propylene glycol monomethyl acetate
  3. Propylene glycol monomethyl ether acetate
  4. Propyleneglycol monomethyl ether acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 750 mg/kg N/R NTIS** AD691-490
oral
rat 		lethal dose (50 percent kill): 8,532 mg/kg N/R DOWCC* MSD-1582
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R DOWCC* MSD-1582


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CRTXB2 30,307,2000


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (275 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (270 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN NGV 50 ppm (230 mg/m3), KTV 75 ppm (350 mg/m3, Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (274 mg/m3), short term exposure limit 150 ppm (822 mg/m3),SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 550 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9258;
Number of Industries 178;
Total Number of Facilities 30,459;
Number of Occupations 109;
Total Number of Employees Exposed 345,446;
Total Number of Female Employees Exposed 40,133


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #99


REFERENCES:

CODEN
REFERENCE
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

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