The Registry of Toxic Effects of Chemical Substances

Acetic acid, methyl ester

RTECS #: AI9100000

CAS #: 79-20-9

UPDATE: November 2004 MW: 74.09 MF: C3H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acetate de methyle (French)
  2. Devoton
  3. Ethyl ester of monoacetic acid
  4. Methyl acetate
  5. Methyl acetate (ACGIH:OSHA)
  6. Methyl ethanoate
  7. Methylacetaat (Dutch)
  1. Methylacetat (German)
  2. Methyle (acetate de) (French)
  3. Methylester kiseliny octove (Czech)
  4. Metile (acetato di) (Italian)
  5. Octan metylu (Polish)
  6. Tereton


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,353,1986
skin
rabbit 		500 mg/24 hour mild FCTXAV 17,859,1979
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,353,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 33,800 ppm MUREAV 149,339,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraduodenal
rabbit 		lethal dose (50 percent kill): 3,700 mg/kg N/R FCTXAV 17,859,1979
inhalation
cat 		lowest published lethal concentration: 67 gm/m3/1 hour Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		AGGHAR 5,1,1933
inhalation
human 		lowest published toxic concentration: 15,000 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes 		AGGHAR 5,1,1933
inhalation
mouse 		lowest published lethal concentration: 34 gm/m3/4 hour Behavioral: General anesthetic AGGHAR 5,1,1933
inhalation
rat 		lowest published lethal concentration: 32,000 ppm/4 hour N/R AIHAAP 23,95,1962
oral
rat 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,859,1979
oral
rabbit 		lethal dose (50 percent kill): 3,705 mg/kg N/R IMSUAI 41,31,1972
subcutaneous
cat 		lowest published lethal dose: 3 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		AGGHAR 5,1,1933
subcutaneous
guinea pig 		lowest published lethal dose: 3 gm/kg N/R AGGHAR 5,1,1933
subcutaneous
rat 		lowest published lethal dose: 8 gm/kg N/R BSIBAC 18,45,1943
skin
guinea pig 		lethal dose (50 percent kill): >20 mL/kg N/R NTIS** OTS0556681
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,859,1979
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 214 mg/kg N/R GISAAA 33(8),107,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 28 gm/m3/40 minute/4 week- intermittent Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature decrease 		NTIS** OTS0572401


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm;short term exposure limit 250 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 250 ppm DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
AMIHAB 21,28,1960


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (610 mg/m3) DTLVS* 3,153,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (610 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (610 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (610 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (610 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (610 mg/m3), short term exposure limit 250 ppm, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (610 mg/m3), short term exposure limit 250 ppm (760 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 150 ppm (455 mg/m3), JAN1999
Occupational Exposure Limit - AUSTRIA MAK 200 ppm (610 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (610 mg/m3), short term exposure limit 250 ppm (765 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 200 ppm (610 mg/m3), VLE 250 ppm (760 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 200 ppm (610 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 200 mg/m3, short term exposure limit 500 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 610 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (305 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (610 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 750 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 200 ppm, short term exposure limit 100 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 150 ppm (450 mg/m3), short term exposure limit 300 ppm (900 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (610 mg/m3), KZG- week 400 ppm (1220 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (610 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (616 mg/m3), short term exposure limit 250 ppm (770 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 250 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 250 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ACETATE-air 10 hour time-weighted average 200 ppm;
short term exposure limit 250 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 46410;
Number of Industries 26;
Total Number of Facilities 1,604;
Number of Occupations 22;
Total Number of Employees Exposed 5,611
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 46410;
Number of Industries 15;
Total Number of Facilities 387;
Number of Occupations 31;
Total Number of Employees Exposed 20,455;
Total Number of Female Employees Exposed 6,018


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl acetate, 1458


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

NIOSH PROFILE (ACETATES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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