The Registry of Toxic Effects of Chemical Substances

Acetic acid, pentyl ester

RTECS #: AJ1925000

CAS #: 628-63-7

UPDATE: May 2004 MW: 130.21 MF: C7H14O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acetate d'amyle (French)
  2. Acetic acid, amyl ester
  3. Birnenoel
  4. Pent - acetate
  5. Pent - acetate 28
  6. 1 - Pentanol acetate
  7. Pentyl acetate
  8. n - Pentyl acetate
  1. 1 - Pentyl acetate
  2. Primary amyl acetate
  3. Amylazetat (German)
  4. Amylester kyseliny octove (Czech)
  5. Amyl acetate
  6. n - Amyl acetate (ACGIH:OSHA)
  7. Amyl acetic ester
  8. Octan amylu (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		300 ppm N/R JIHTAB 25,282,1943


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 5,000 mg/m3/30 minute Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes 		AHYGAJ 78,260,1913
inhalation
rat 		lethal concentration : >3,000 ppm/6 hour N/R NTIS** OTS0558878
intraperitoneal
guinea pig 		lowest published lethal dose: 1,500 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases AIHAAP 35,21,1974
oral
rat 		lethal dose (50 percent kill): >1,600 mg/kg N/R NTIS** OTS0556694
oral
rabbit 		lethal dose (50 percent kill): 7,400 mg/kg N/R 85JCAE -,357,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 600 ppm/2 week- intermittent Behavioral: Somnolence (general depressed activity) JJATDK 20,463,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm; short term exposure limit 100 ppm DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 100 ppm DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
AMIHAB 21,28,1960


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,292,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (525 mg/m3) DTLVS* 3,12,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (525 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (525 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (525 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (525 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 100 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (530 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 100 ppm (530 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (260 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 250 mg/m3, MAC(short term exposure limit) 500 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 100 ppm (500 mg/m3), short term exposure limit 150 ppm (800 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (500 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (270 mg/m3), short term exposure limit 100 ppm (541 mg/m3),SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-AMYL ACETATE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1226;
Number of Industries 48;
Total Number of Facilities 4,502;
Number of Occupations 56;
Total Number of Employees Exposed 37,718
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1226;
Number of Industries 142;
Total Number of Facilities 21,065;
Number of Occupations 108;
Total Number of Employees Exposed 265,437;
Total Number of Female Employees Exposed 91,128


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AHYGAJ Archiv fuer Hygiene. (Munich, Fed. Rep. Ger.) V.1-100, 1883-1928. For publisher information, see ZHPMAT.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

NIOSH PROFILE (ACETATES), SRI, 2/77

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Human Data
   Natural Product
   Primary Irritant

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