The Registry of Toxic Effects of Chemical Substances

Acetic anhydride

RTECS #: AK1925000

CAS #: 108-24-7

UPDATE: November 2004 MW: 102.10 MF: C4H6O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acetanhydride
  2. Acetic acid, anhydride (9CI)
  3. Acetyl ether
  4. Essigsaeureanhydrid (German)
  5. Ethanoic anhydrate
  6. Acetic anhydride (ACGIH:OSHA)
  7. Acetic oxide
  1. Acetyl anhydride
  2. Acetyl oxide
  3. Anhydride acetique (French)
  4. Anhydrid kyseliny octove (Czech)
  5. Anidride acetica (Italian)
  6. Azijnzuuranhydride (Dutch)
  7. Octowy bezwodnik (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		540 mg open irritation test mild UCDS** 8/7/1963


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 1,000 ppm/4 hour N/R 34ZIAG -,607,1969
oral
rat 		lethal dose (50 percent kill): 1,780 mg/kg N/R AMIHBC 4,119,1951
skin
rabbit 		lethal dose (50 percent kill): 4 mL/kg N/R UCDS** 8/7/1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2,470 µg/m3/24 hour/95 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 34(4),103,1969
inhalation
rat 		lowest published toxic concentration: 400 ppm/6 hour/2 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0556144


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 5 ppm (20 mg/m3) DTLWS* 3,2,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (20 mg/m2), JAN1999
Occupational Exposure Limit - FRANCE VLE 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit( continuous) 5 ppm (21 mg/m3), JAN1999
Occupational Exposure Limit - POLAND time-weighted average 10 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN CEILING 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.5 mg/m3), short term exposure limit 0.4 ppm (2 mg/m3), SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETIC ANHYDRIDE-air ceiling concentration 5 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 02740;
Number of Industries 23;
Total Number of Facilities 3,012;
Number of Occupations 16;
Total Number of Employees Exposed 19,365
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 02740;
Number of Industries 73;
Total Number of Facilities 7,514;
Number of Occupations 59;
Total Number of Employees Exposed 92,428;
Total Number of Female Employees Exposed 11,630


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in application and synthesis of CELLULOSE ACETATE, films and fibers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acetic anhydride, 3506
OSHA ANALYTICAL METHOD #102


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in application and synthesis of CELLULOSE ACETATE, films and fibers

NIOSH PROFILE (ORGANIC ANHYDRIDES), SRC, 2/82

RTECS Compound Description:
   Primary Irritant

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