The Registry of Toxic Effects of Chemical Substances

Acetin, tri -

RTECS #: AK3675000

CAS #: 102-76-1

UPDATE: February 2003 MW: 218.23 MF: C9H14O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Enzactin
  2. Fungacetin
  3. Glycerin triacetate
  4. Glycerol triacetate
  5. Glyceryl triacetate
  6. Glyped
  7. Kesscoflex TRA
  1. Kodaflex triacetin
  2. Triacetin
  3. Triacetine
  4. Triacetyl glycerine
  5. Vanay
  6. 1,2,3 - Propanetriol triacetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		116 mg N/R JPETAB 82,377,1944


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/6 hour (+enzymatic activation step) MUREAV 517,187,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
guinea pig 		lowest published lethal dose: 1,740 mg/kg Lung, Thorax, or Respiration: Dyspnea JPETAB 76,189,1942
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,400 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Stiffness 		FEPRA7 22,368,1963
intraperitoneal
rat 		lethal dose (50 percent kill): 2,100 mg/kg N/R FCTXAV 16,879,1978
intravenous
dog 		lethal dose (50 percent kill): 1,500 mg/kg N/R FCTXAV 16,879,1978
intravenous
mouse 		lethal dose (50 percent kill): 1,600 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		APSCAX 40,338,1957
intravenous
rabbit 		lethal dose (50 percent kill): 750 mg/kg N/R FCTXAV 16,879,1978
oral
frog 		lowest published lethal dose: 150 mg/kg N/R FCTXAV 16,879,1978
oral
mouse 		lethal dose (50 percent kill): 1,100 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Stiffness 		FEPRA7 22,368,1963
oral
rat 		lethal dose (50 percent kill): 3 gm/kg N/R AMIHAB 21,28,1960
subcutaneous
mouse 		lethal dose (50 percent kill): 2,300 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		PSEBAA 46,26,1941
subcutaneous
rat 		lethal dose (50 percent kill): 2,800 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		PSEBAA 46,26,1941


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1910;
Number of Industries 17;
Total Number of Facilities 832;
Number of Occupations 25;
Total Number of Employees Exposed 11,313
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1910;
Number of Industries 13;
Total Number of Facilities 713;
Number of Occupations 21;
Total Number of Employees Exposed 18,436;
Total Number of Female Employees Exposed 4,103


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
APSCAX Acta Physiologica Scandinavica. (Karolinska Institutet, S-10401 Stockholm, Sweden) V.1- 1940-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-

Used as solvent for essential oils

FDA-over the counter drug

RTECS Compound Description:
   Drug
   Mutagen
   Primary Irritant

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