The Registry of Toxic Effects of Chemical Substances

Acetoacetic acid, ethyl ester

RTECS #: AK5250000

CAS #: 141-97-9

UPDATE: January 1997 MW: 130.16 MF: C6H10O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Butanoic acid, 3 - oxo - , ethyl ester
  2. Diacetic ether
  3. EAA
  4. Ethylacetacetat (Czech)
  5. Ethyl acetoacetate
  6. Ethyl acetyl acetate
  7. Ethyl acetylacetonate
  1. Ethylester kyseliny acetoctove (Czech)
  2. Ethyl 3 - oxobutanoate
  3. Ethyl 3 - oxobutyrate
  4. 3 - Oxobutanoic acid ethyl ester
  5. Acetoacetic ester
  6. Acetoctan ethylnaty (Czech)
  7. Active acetyl acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe AJOPAA 29,1363,1946
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,729,1986
skin
rabbit 		510 mg open irritation test mild UCDS** 3/12/1969


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 21 mg/disc OIGZDE 34,267,1985
mutation in microorganisms Escherichia coli 200 µg/plate (-enzymatic activation step) OIGZDE 34,267,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 5,105 mg/kg N/R JPMSAE 60,1810,1971
oral
rat 		lethal dose (50 percent kill): 3,980 mg/kg N/R JIHTAB 31,60,1949
skin
rabbit 		lethal dose : >20 mL/kg N/R UCDS** 3/12/1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84283;
Number of Industries 2;
Total Number of Facilities 49;
Number of Occupations 16;
Total Number of Employees Exposed 2,518
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84283;
Number of Industries 10;
Total Number of Facilities 678;
Number of Occupations 9;
Total Number of Employees Exposed 6,334;
Total Number of Female Employees Exposed 1,863


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

NIOSH PROFILE (ACETATES), SRI, 2/77

RTECS Compound Description:
   Drug
   Mutagen
   Primary Irritant

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