The Registry of Toxic Effects of Chemical Substances

Acetoacetic acid, methyl ester

RTECS #: AK5775000

CAS #: 105-45-3

UPDATE: February 2003 MW: 116.13 MF: C5H8O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Butanoic acid, 3 - oxo - , methyl ester (9CI)
  2. Methylacetoacetate
  3. Methyl acetylacetate
  4. Methyl acetylacetonate
  5. Methylester kyseliny acetoctove (Czech)
  1. Methyl 3 - oxobutanoate
  2. Methyl 3 - oxobutyrate
  3. 3 - Oxobutanoic acid methyl ester
  4. Acetoacetic methyl ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		2 mg severe AJOPAA 29,1363,1946
skin
rabbit 		10 mg/24 hour open irritation test severe JIHTAB 30,63,1948
skin
rabbit 		500 mg/24 hour mild FCTXAV 16,815,1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/6 hour (+enzymatic activation step) MUREAV 517,187,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 3,228 mg/kg N/R JIHTAB 30,63,1948


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84355;
Number of Industries 1;
Total Number of Facilities 23;
Number of Occupations 1;
Total Number of Employees Exposed 270
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84355;
Number of Industries 2;
Total Number of Facilities 30;
Number of Occupations 5;
Total Number of Employees Exposed 1,872;
Total Number of Female Employees Exposed 336


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

RTECS Compound Description:
   Mutagen
   Primary Irritant

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