The Registry of Toxic Effects of Chemical Substances

Acetic acid, vinyl ester

RTECS #: AK0875000

CAS #: 108-05-4

UPDATE: May 2005 MW: 86.10 MF: C4H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1 - Acetoxyethylene
  2. Acetate de vinyle (French)
  3. Acetic acid, ethenyl ester
  4. Acetic acid, ethylene ether
  5. Acetoxyethene
  6. Ethanoic acid, ethenyl ester
  7. Ethenyl acetate
  8. Ethenyl ethanoate
  9. Octan winylu (Polish)
  10. VAC
  11. VYAC
  1. Vinile (acetato di) (Italian)
  2. Vinyl A monomer
  3. Vinyl acetate
  4. Vinyl acetate (ACGIH)
  5. Vinyl acetate H.Q.
  6. Vinyl ethanoate
  7. Vinylacetaat (Dutch)
  8. Vinylacetat (German)
  9. Vinyle (acetate de) (French)
  10. Vinylester kyseliny octove (Czech)
  11. Zeset T


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		22 ppm N/R AIHAAP 30,449,1969


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 250 µmol/L MUREAV 159,109,1986
micronucleus test human lymphocyte 500 µmol/L MUREAV 190,41,1987
micronucleus test intraperitoneal
mouse 		1 gm/kg MUREAV 190,41,1987
morphological transform hamster embryo 62,500 µg/L AETODY 1,241,1980
sister chromatid exchange hamster ovary 125 µmol/L CNREA8 45,4816,1985
sister chromatid exchange human lymphocyte 100 µmol/L CNREA8 45,4816,1985
sperm morphology intraperitoneal
mouse 		2,500 mg/kg/5 day MUREAV 202,171,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FAATDF 24,198,1995
oral
rat 		lowest published toxic dose: 500 mg/kg (multigenerations) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) EPASR* 8EHQ-0185-0543
oral
rat 		lowest published toxic dose: 91 gm/kg (multigeneration) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FAATDF 24,206,1995
oral
rat 		lowest published toxic dose: 4,770 mg/kg (6-15 day pregnant) Reproductive: Other effects on female NTIS** OTS0535164


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 600 ppm/6 hour/5 day/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		EPASR* 8EHQ-0187-0650
inhalation
rat 		lowest published toxic concentration: 600 ppm/6 hour/5 day/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		EPASR* 8EHQ-0187-0650
oral
rat 		lowest published toxic dose: 100 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors

Reproductive: Tumorigenic effects: Uterine tumors 		TXAPA9 68,43,1983


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 6,200 ppm/4 hour N/R NTIS** OTS0521596
inhalation
mouse 		lethal concentration (50 percent kill): 1,550 ppm/4 hour N/R DUPON* ES-3574,1975
inhalation
rat 		lethal concentration (50 percent kill): 11,400 mg/m3/4 hour N/R GTPZAB 25(11),57,1981
inhalation
rabbit 		lethal concentration (50 percent kill): 2,500 ppm/4 hour N/R 85INA8 5,621,1986
intraperitoneal
guinea pig 		lowest published lethal dose: 500 mg/kg Liver: Fatty liver degeneration AIHAAP 35,21,1974
oral
mouse 		lethal dose (50 percent kill): 1,600 mg/kg N/R NTIS** OTS0521596
oral
rat 		lethal dose (50 percent kill): 2,900 mg/kg N/R NTIS** OTS0521596
skin
rabbit 		lethal dose (50 percent kill): 2,335 mg/kg N/R DUPON* ES-3574,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 1,000 ppm/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0521599
inhalation
mouse 		lowest published toxic concentration: 600 ppm/6 hour/2 year- intermittent Lung, Thorax, or Respiration: Other changes NTIS** OTS0521599
inhalation
rat 		lowest published toxic concentration: 600 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects INHTE5 9,331,1997
inhalation
rat 		lowest published toxic concentration: 250 ppm/6 hour/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0521599
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0521599
inhalation
rat 		lowest published toxic concentration: 2,500 ppm/4 hour/1 year- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** OTS0521599
oral
mouse 		lowest published toxic dose: 6,300 mg/kg/20 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field GISAAA 31(8),19,1966
oral
rat 		lowest published toxic dose: 21 mg/kg/30 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 31(8),19,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm;short term exposure limit 15 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 15 ppm DTLVS* TLV/BEI,2002
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 63,443,1995
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 39,113,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,113,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 63,443,1995
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 63,443,1995
TOXICOLOGY REVIEW
ARPTDI 43,485,2003
TOXICOLOGY REVIEW
TOLED5 138,9,2003
TOXICOLOGY REVIEW
TOLED5 140-141,43,2003
TOXICOLOGY REVIEW
TOLED5 140-141,83,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (30 mg/m3) DTLVS* 3,276,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (30 mg/m3), short term exposure limit 20 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1 ppm (35 mg/m3), Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (35 mg/m3), short term exposure limit 20 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (35 mg/m3), short term exposure limit 20 ppm (70 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 10 ppm (35 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 18 mg/m3, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3, MAC(short term exposure limit) 30 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 5 ppm (18 mg/m3), KTV 10 ppm (35 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (35 mg/m3), KZG- week 20 ppm (70 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 10 ppm (30 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (36 mg/m3), short term exposure limit 20 ppm (72 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 15 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 15 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL ACETATE-air ceiling concentration 4 ppm/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 76420;
Number of Industries 62;
Total Number of Facilities 5,046;
Number of Occupations 59;
Total Number of Employees Exposed 50,282
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6624;
Number of Industries 79;
Total Number of Facilities 6,264;
Number of Occupations 71;
Total Number of Employees Exposed 129,024;
Total Number of Female Employees Exposed 36,642


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110898/AS)
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of POLYVINYL ACETATE homopolymer emulsions and resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Vinyl acetate, 1453
OSHA ANALYTICAL METHOD #51


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DUPON* E.I. Dupont de Nemours and Company, Technical Sheet. (1007 Market St., Wilmington, DE 19898)
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in the production of POLYVINYL ACETATE homopolymer emulsions and resins

Top 50 chemical production: 2.66 billions lbs in 1992, 2.73 billions in 1991

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 61891-42-7
ALT CAS #: 82041-23-4
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