The Registry of Toxic Effects of Chemical Substances
Acetonitrile, chloro - RTECS #: AL8225000
CAS #: 107-14-2
The Registry of Toxic Effects of Chemical Substances
Acetonitrile, chloro - |
| UPDATE: February 2003 | MW: 75.50 | MF: C2H2ClN |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
eye | rabbit
20 mg/24 hour
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moderate
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85JCAE -,907,1986
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skin | rabbit
14 mg/24 hour open irritation test
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mild
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AIHAAP 23,95,1962
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skin | rabbit
500 mg/24 hour
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mild
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85JCAE -,907,1986
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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DNA damage
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human
lymphocyte
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15 µmol/L
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NTIS** PB84-246230
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DNA damage
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human
HeLa cell
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10 µmol/L/30 minute
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EMMUEG 36,52,2000
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unscheduled DNA synthesis
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oral | rat
115 mg/kg
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TOXID9 13,220,1993
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mutation in microorganisms
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Salmonella typhimurium
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30 mg/L (+enzymatic activation step)
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MUREAV 341,289,1995
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mutation in microorganisms
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Salmonella typhimurium
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0.13 mmol/L/72 hour (-enzymatic activation step)
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EMMUEG 36,52,2000
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micronucleus test
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multiple | non-mammalian species
1,250 µg/L
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MUREAV 341,289,1995
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sister chromatid exchange
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hamster
ovary
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79,100 nmol/L
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FAATDF 5,1065,1985
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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skin | mouse
lowest published toxic dose: 4,800 mg/kg/2 week- intermittent
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Tumorigenic: Carcinogenic by RTECS criteria | Skin and Appendages: Tumors
FAATDF 5,1065,1985
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published lethal concentration: 250 ppm/4 hour
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N/R
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AIHAAP 23,95,1962
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intraperitoneal | mouse
lethal dose (50 percent kill): 100 mg/kg
|
N/R
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NTIS** AD277-689
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oral | mouse
lethal dose (50 percent kill): 139 mg/kg
|
N/R
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ARTODN 55,47,1984
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oral | rat
lethal dose (50 percent kill): 220 mg/kg
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N/R
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AIHAAP 23,95,1962
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skin | rabbit
lethal dose (50 percent kill): 71 µL/kg
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N/R
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AIHAAP 23,95,1962
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review
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Animal Inadequate Evidence
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IMEMDT 52,269,1991
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International Agency for Research on Cancer (IARC) Cancer Review
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Animal Inadequate Evidence
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IMEMDT 71,1325,1999
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International Agency for Research on Cancer (IARC) Cancer Review
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Human No Available Data
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IMEMDT 52,269,1991
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International Agency for Research on Cancer (IARC) Cancer Review
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Human No Adequate Data
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IMEMDT 71,1325,1999
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International Agency for Research on Cancer (IARC) Cancer Review
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Group 3
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IMEMDT 71,1325,1999
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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AIHAAP
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American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH
44311) V.19- 1958-
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ARTODN
|
Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep.
Ger.) V.32- 1974-
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EMMUEG
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Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
10003) V.10- 1987-
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FAATDF
|
Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1-40, 1981-97. For publisher information, see TOSCF2
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IMEMDT
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IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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TOXID9
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Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
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