The Registry of Toxic Effects of Chemical Substances

Acetophenone, 2 - chloro -

RTECS #: AM6300000

CAS #: 532-27-4

UPDATE: November 2004 MW: 154.60 MF: C8H7ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Chloroacetophenone
  2. 2 - Chloro - 1 - phenylethanone
  3. 2 - Chloroacetophenone
  4. CN
  5. Chemical mace
  6. Chloromethyl phenyl ketone
  7. Ethanone, 2 - chloro - 1 - phenyl -
  1. Mace (lacrimator)
  2. NCI - C55107
  3. Phenacyl chloride
  4. Phenylchloromethylketone
  5. alpha - Chloroacetophenone
  6. alpha - Chloroacetophenone (ACGIH:OSHA)
  7. omega - Chloroacetophenone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg mild TXAPA9 17,295,1970
eye
rabbit 		3 mg severe TXAPA9 17,295,1970
eye
rabbit 		2% rinse mild ARTODN 34,183,1975
eye
rabbit 		1% VCVGK* -,463,1994
skin
guinea pig 		12%/6 hour open irritation test moderate ARTODN 40,75,1978
skin
human 		0.5 mg/1 hour moderate CODEDG 86,150,1972
skin
rat 		12%/6 hour open irritation test moderate ARTODN 40,75,1978
skin
rabbit 		5 mg/24 hour mild TXAPA9 17,295,1970
skin
rabbit 		12%/6 hour open irritation test moderate ARTODN 40,75,1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 3 mg/L NTPTR* NTP-TR-379,1990
DNA damage rat liver 10 µmol/L MUREAV 368,59,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2 mg/m3/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors

Skin and Appendages: Tumors 		NTPTR* NTP-TR-379,1990
skin
mouse 		lowest published toxic dose: 2,400 mg/kg/27 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		BJCAAI 7,482,1953


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		lowest published toxic dose: 5 pph Eye: Corneal damage VCVGK* -,463,1994
inhalation
guinea pig 		lowest published lethal concentration: 490 mg/m3/30 minute Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		ARTODN 40,75,1978
inhalation
human 		lowest published lethal concentration: 159 mg/m3/20 minute N/R 34ZIAG -,163,1969
inhalation
human 		lowest published toxic concentration: 93 mg/m3/3 minute Eye: Lacrimation

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Dyspnea 		AIHAAP 23,199,1962
inhalation
human 		lowest published toxic concentration: 20 mg/m3 Eye: Other eye effects

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea 		BJIMAG 29,298,1972
inhalation
human 		lowest published toxic concentration: 0.5 mg/m3/10S Eye: Conjunctiva irritation VCVGK* -,463,1994
inhalation
mouse 		lethal concentration (50 percent kill): 59 mg/m3 N/R GISAAA 58(10),4,1993
inhalation
rat 		lowest published lethal concentration: 417 mg/m3/15 minute Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		ARTODN 40,75,1978
inhalation
rabbit 		lowest published lethal concentration: 465 mg/m3/20 minute Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		ARTODN 40,75,1978
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 17 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair 		ARTODN 40,75,1978
intraperitoneal
mouse 		lethal dose (50 percent kill): 60 mg/kg N/R NTIS** AD837-111
intraperitoneal
rat 		lethal dose (50 percent kill): 36 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair 		ARTODN 40,75,1978
intravenous
mouse 		lethal dose (50 percent kill): 81 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes 		ARTODN 40,75,1978
intravenous
rat 		lethal dose (50 percent kill): 41 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes 		ARTODN 40,75,1978
intravenous
rabbit 		lethal dose (50 percent kill): 30 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes 		ARTODN 40,75,1978
oral
guinea pig 		lethal dose (50 percent kill): 158 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair 		ARTODN 40,75,1978
oral
mouse 		lethal dose (50 percent kill): 139 mg/kg N/R NTIS** AD837-111
oral
rat 		lethal dose (50 percent kill): 50 mg/kg N/R TXAPA9 17,295,1970
oral
rabbit 		lethal dose (50 percent kill): 118 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair 		ARTODN 40,75,1978
skin
guinea pig 		lethal dose (50 percent kill): >1 gm/kg N/R NTIS** OTS0556684


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 10 mg/m3/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-379,1990
inhalation
mouse 		lowest published toxic concentration: 87.6 mg/m3/15 minute/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Lung, Thorax, or Respiration: Other changes

Endocrine: Hyperglycemia 		JAPTO* 14,411,1994
inhalation
rat 		lowest published toxic concentration: 19 mg/m3/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-379,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 ppm (0.3 mg/m3) DTLVS* 3,48,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 ppm (0.3 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.05 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.32 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.05 ppm (0.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 0.05 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.05 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.3 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit UNITED KINGDOM;
time-weighted average 0.05 ppm (0.32 mg/m3),SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-CHLOROACETOPHENONE-air 10 hour time-weighted average 0.05 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4754;
Number of Industries 1;
Total Number of Facilities 35;
Number of Occupations 4;
Total Number of Employees Exposed 2,294;
Total Number of Female Employees Exposed 1,412


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat
NCI Carcinogenesis Studies (inhal);no evidence:mouse


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as an industrial chemical

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

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