The Registry of Toxic Effects of Chemical Substances

Acrylic acid, 2,2 - dimethyltrimethylene ester

RTECS #: AS8925000

CAS #: 2223-82-7

UPDATE: September 2000 MW: 212.27 MF: C11H16O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Acrylic acid, 2,2 - dimethyl - 1,3 - propanediol diester
  2. Dimethylolpropane diacrylate
  3. 2,2 - Dimethyltrimethylene acrylate
  4. Neopentyl glycol diacrylate
  1. SR 247
  2. Viscoat 247
  3. 1,3 - Propanediol, 2,2 - dimethyl - , diacrylate
  4. 2 - Propenoic acid, 2,2 - dimethyl - 1,3 - propanediyl ester (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg open irritation test severe UCDS** 11/30/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 46,800 mg/kg/28 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JTEHD6 16,55,1985


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 230 µL/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema 		NTIS** OTS0537547
oral
rat 		lethal dose (50 percent kill): 5,190 µL/kg N/R UCDS** 10/5/1977
skin
rabbit 		lethal dose (50 percent kill): 180 µL/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage

Skin: After systemic exposure: Dermatitis, other 		NTIS** OTS0537547


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83743;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 5;
Total Number of Employees Exposed 1,264


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as diluent for ultraviolet irradiation-cured systems such as coatings, laminates
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as diluent for ultraviolet irradiation-cured systems such as coatings, laminates

RTECS Compound Description:
   Tumorigen
   Primary Irritant

 Click Here for Additional Information about RTECS