The Registry of Toxic Effects of Chemical Substances

Acrylic acid, methyl ester

RTECS #: AT2800000

CAS #: 96-33-3

UPDATE: November 2004 MW: 86.10 MF: C4H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Propenoic acid, methyl ester (9CI)
  2. Acrylate de methyle (French)
  3. Acrylsaeuremethylester (German)
  4. Curithane 103
  5. Methoxycarbonylethylene
  6. Methyl acrylate
  7. Methyl acrylate (ACGIH:OSHA)
  1. Methyl propenate
  2. Methyl propenoate
  3. Methyl - 2 - propenoate
  4. Methyl - acrylat (German)
  5. Methylacrylaat (Dutch)
  6. Methylester kyseliny akrylove (Czech)
  7. Metilacrilato (Italian)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rat 		578 ppm/49 hour- intermittent N/R JIHTAB 31,317,1949
eye
rabbit 		100 mg severe AJOPAA 29,1363,1946
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,368,1986
skin
rabbit 		1,00%/1 minute immersion moderate JIHTAB 31,317,1949
skin
rabbit 		10 mg/24 hour open irritation test moderate JIHTAB 30,63,1948


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 189 ppm ESKHA5 (102),77,1984
cytogenetic analysis hamster lung 6,500 µg/L GMCRDC 27,95,1981
cytogenetic analysis mouse lymphocyte 22 mg/L ENMUDM 8(Suppl 6),4,1986
mutation in microorganisms mouse lymphocyte 22 mg/L (+enzymatic activation step) ENMUDM 8(Suppl 6),4,1986
micronucleus test intraperitoneal
mouse 		37,500 µg/kg MUREAV 135,189,1984
mutation in mammalian somatic cells mouse lymphocyte 14 mg/L EMMUEG 11,49,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOSCF2 48,240,1999
inhalation
rat 		lowest published toxic concentration: 100 ppm (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female 		TOSCF2 48,240,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 75 ppm Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes 		34ZIAG -,75,1969
inhalation
mouse 		lethal concentration (50 percent kill): 12,800 mg/m3 N/R GTPZAB 23(9),55,1979
inhalation
rat 		lethal concentration (50 percent kill): 1,350 ppm/4 hour Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea 		JTEHD6 16,811,1985
inhalation
rabbit 		lowest published lethal concentration: 2,522 ppm/1 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		JIHTAB 31,317,1949
intraperitoneal
mouse 		lethal dose (50 percent kill): 254 mg/kg N/R JDREAF 51,526,1972
intraperitoneal
rat 		lethal dose (50 percent kill): 325 mg/kg N/R AMPMAR 36,58,1975
oral
mouse 		lethal dose (50 percent kill): 827 mg/kg N/R TOLED5 11,125,1982
oral
rat 		lethal dose (50 percent kill): 277 mg/kg N/R AMPMAR 36,58,1975
oral
rabbit 		lowest published lethal dose: 280 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea 		JIHTAB 31,317,1949
skin
rabbit 		lethal dose (50 percent kill): 1,243 mg/kg N/R JIHTAB 30,63,1948


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 µg/m3/24 hour/14 week- continuous Behavioral: Muscle contraction or spasticity

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in spleen 		GISAAA 32(10),3,1967
inhalation
rat 		lowest published toxic concentration: 71 mg/m3/3 hour/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS GISAAA 45(1),34,1980
oral
rat 		lowest published toxic dose: 109 gm/kg/2 year- continuous Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 6,29,1964
skin
guinea pig 		lowest published toxic dose: 5 pph/12 week- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 9,55,1983


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin, sen) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,99,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1489,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 39,99,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,1489,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1489,1999
TOXICOLOGY REVIEW
EVHPAZ 11,141,1975
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (35 mg/m3) (skin) DTLVS* 3,154,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (35 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (35 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (35 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (35 mg/m3), short term exposure limit 20 ppm (70 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 10 ppm (35 mg/m3), VLE 15 ppm (50 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 20 mg/m3, short term exposure limit 40 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 18 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (35 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (35 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 20 mg/m3, MAC(short term exposure limit) 70 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 10 ppm (35 mg/m3), KTV 15 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (18 mg/m3), KZG- week 10 ppm (36 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 10 ppm (35 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (36 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ACRYLATE-air 10 hour time-weighted average 10 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 46450;
Number of Industries 22;
Total Number of Facilities 931;
Number of Occupations 14;
Total Number of Employees Exposed 11,809
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 46450;
Number of Industries 6;
Total Number of Facilities 129;
Number of Occupations 16;
Total Number of Employees Exposed 9,762;
Total Number of Female Employees Exposed 3,877


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in production of acrylates, copolymers, barrier resins and surfactants for shampoos
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl acrylate, 1459
OSHA ANALYTICAL METHOD #92


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in production of acrylates, copolymers, barrier resins and surfactants for shampoos

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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