The Registry of Toxic Effects of Chemical Substances

Acrylic acid, 2 - ethylhexyl ester

RTECS #: AT0855000

CAS #: 103-11-7

UPDATE: February 2003 MW: 184.31 MF: C11H20O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Ethylhexyl acrylate
  2. 2 - Ethylhexylester kyseliny akrylove (Czech)
  3. 2 - Ethylhexyl 2 - propenoate
  1. 1 - Hexanol, 2 - ethyl - , acrylate
  2. Octyl acrylate
  3. 2 - Propenoic acid, 2 - ethylhexyl ester (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 mg severe AJOPAA 29,1363,1946
eye
rabbit 		500 mg/24 hour mild 85JCAE -,372,1986
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,372,1986
skin
rabbit 		500 mg open irritation test mild UCDS** 11/3/1971
skin
rabbit 		10 mg/24 hour open irritation test severe AMIHBC 4,119,1951


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in mammalian somatic cells mouse other cell types 70 µg/L EPASR* #FYI-OTS-1284-0367


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 187 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JTEHD6 16,55,1985
skin
mouse 		toxic dose : 240 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		EPASR* 8EHQ-1079-0262


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): >450 mg/m3 Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 56(12),19,1991
inhalation
mouse 		lowest published lethal concentration: 600 mg/m3 Behavioral: Excitement GTPZAB 26(9),52,1982
inhalation
rat 		lowest published toxic concentration: 6.2 gm/m3/6 hour Liver: Other changes

Endocrine: Hyperglycemia

Biochemical: Metabolism (intermediary): Other 		TXCYAC 65,209,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,326 mg/kg N/R JDREAF 51,526,1972
intraperitoneal
rat 		lethal dose (50 percent kill): 1,670 mg/kg N/R AMPMAR 36,58,1975
oral
mouse 		lethal dose (50 percent kill): 4,400 mg/kg Behavioral: Excitement GTPZAB 26(9),52,1982
oral
mouse 		lethal dose (50 percent kill): 4,400 mg/kg N/R GTPRZ* -,52,1982
oral
rat 		lethal dose (50 percent kill): 6,500 µL/kg N/R UCDS** 11/3/1971
oral
rat 		lethal dose (50 percent kill): 6,700 mg/kg N/R GISAAA -,16,1993
oral
rabbit 		lowest published lethal dose: >4 mL/kg N/R NTIS** OTS0520808
skin
rat 		lethal dose : >12 gm/kg N/R PJPPAA 32,223,1980
skin
rabbit 		lethal dose (50 percent kill): 8,480 µL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 103 mg/m3/19 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Endocrine: Changes in thyroid weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GTPZAB 26(9),52,1982
inhalation
rat 		lowest published toxic concentration: 1 mg/m3/24 hour/17 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		GISAAA 56(12),19,1991
oral
rat 		lowest published toxic dose: 4,020 mg/kg/30 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GISAAA 58(3),16,1993
oral
rat 		lowest published toxic dose: 1,785 mg/kg/26 week- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 58(3),16,1993
oral
rat 		lowest published toxic dose: 810 mg/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		GISAAA -,16,1993
oral
rat 		lowest published toxic dose: 2,680 mg/kg/20 day- intermittent Behavioral: Change in psychophysiological tests

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GISAAA -,16,1993
oral
rat 		lowest published toxic dose: 900 mg/kg/60 day- intermittent Behavioral: Change in psychophysiological tests

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA -,16,1993
oral
rat 		lowest published toxic dose: 360 mg/kg/120 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA -,16,1993
oral
rat 		lowest published toxic dose: 450 mg/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		GISAAA -,16,1993
oral
rat 		lowest published toxic dose: 270 mg/kg/90 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		GISAAA -,16,1993
oral
rat 		lowest published toxic dose: 450 mg/kg/150 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		GISAAA -,16,1993
oral
rat 		lowest published toxic dose: 547.5 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		GISAAA -,16,1993
skin
guinea pig 		lowest published toxic dose: 5 pph/12 week- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 9,55,1983
skin
mouse 		lowest published toxic dose: 21 pph/2 year- intermittent Skin and Appendages: Tumors

Nutritional and Gross Metabolic: Other changes

Tumorigenic: Tumors at site of application 		EPASR* FYI-OTS-0887-0367
skin
mouse 		lowest published toxic dose: 23,040 mg/kg/2 year- intermittent Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		EPASR* 8EHQ-1079-0262
skin
mouse 		lowest published toxic dose: 20,160 mg/kg/84 week- intermittent Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		EPASR* 88-7800262
skin
mouse 		lowest published toxic dose: 230,400 mg/kg/2 year- intermittent Kidney, Ureter, and Bladder: Interstitial nephritis

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		EPASR* 88-7800262


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 60,475,1994
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,475,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 60,475,1994
TOXICOLOGY REVIEW
EVHPAZ 11,141,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - POLAND time-weighted average 35 mg/m3, short term exposure limit 100 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82082;
Number of Industries 17;
Total Number of Facilities 1,437;
Number of Occupations 24;
Total Number of Employees Exposed 26,428
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82082;
Number of Industries 10;
Total Number of Facilities 592;
Number of Occupations 12;
Total Number of Employees Exposed 11,277;
Total Number of Female Employees Exposed 2,341


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in production of emulsion polymers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPRZ* Gigiena truda i professional'nye zabolevaniia. (Moskva Izdatelstvo Meditsina. Continued by:Meditsina truda i promyshlennaia ekologiia) V.1- 1953-1992
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information, see PJPAE3
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in production of emulsion polymers

NIOSH PROFILE (ACRYLIC ACID and ESTERS), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

ALT CAS #: 78733-32-1
ALT CAS #: 84948-57-2
ALT CAS #: 93460-77-6
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