The Registry of Toxic Effects of Chemical Substances

Allylamine

RTECS #: BA5425000

CAS #: 107-11-9

UPDATE: February 2004 MW: 57.11 MF: C3H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 3 - Aminopropene
  2. 3 - Aminopropylene
  3. Monoallylamine
  1. 2 - Propenamine
  2. 2 - Propen - 1 - amine (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 mg/20S rinse severe AEHLAU 1,343,1960
skin
rabbit 		500 mg/24 hour severe AEHLAU 1,343,1960


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
rat 		2,500 ng/kg GISAAA 48(1),80,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 320 mg/m3 N/R TPKVAL 14,80,1975
inhalation
man 		lowest published toxic concentration: 2,500 ppb/5 minute Eye: Lacrimation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi 		AEHLAU 1,343,1960
inhalation
rat 		lethal concentration (50 percent kill): 177 ppm/8 hour Olfaction: Other olfaction effects

Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea 		AEHLAU 1,343,1960
intraperitoneal
mouse 		lethal dose (50 percent kill): 49 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion 		AEHLAU 1,343,1960
intraperitoneal
rat 		lowest published lethal dose: 37,500 µg/kg N/R FATOAO 31,238,1968
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 78,300 µg/kg N/R GISAAA 39(4),86,1974
oral
mouse 		lethal dose (50 percent kill): 57 mg/kg N/R AEHLAU 1,343,1960
oral
rat 		lethal dose (50 percent kill): 102 mg/kg N/R 85GMAT -,17,1982
skin
rabbit 		lethal dose (50 percent kill): 35 mg/kg Skin: After topical application: Primary irritation

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion 		AEHLAU 1,343,1960
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 783 mg/kg N/R TPKVAL 14,80,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 ppm/7 hour/50 day- intermittent Cardiac: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AEHLAU 1,343,1960
oral
rat 		lowest published toxic dose: 1 gm/kg/11 day- intermittent Cardiac: Changes in coronary arteries

Cardiac: Other changes

Vascular: Structural changes in vessels 		TXAPA9 103,288,1990
oral
rat 		lowest published toxic dose: 6,240 mg/kg/15 week- continuous Cardiac: Cardiomyopathy including infarction

Cardiac: Changes in heart weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 50,581,1979
oral
rat 		lowest published toxic dose: 700 mg/kg/20 day- intermittent Vascular: Structural changes in vessels

Biochemical: Metabolism (intermediary): Other proteins 		TOXID9 72,95,2003
oral
rabbit 		lowest published toxic dose: 4,500 µg/kg/26 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 48(1),80,1983


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TXCYAC 44,129,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (4.7 mg/m3), Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 2 ppm (5 mg/m3), KTV 6 ppm (14 mg/m3), Skin, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0127;
Number of Industries 1;
Total Number of Facilities 13;
Number of Occupations 2;
Total Number of Employees Exposed 27


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of mercurial diuretics
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used in the manufacture of mercurial diuretics

NIOSH PROFILE (AMINES, PRIMARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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