The Registry of Toxic Effects of Chemical Substances

Ammonium hydroxide

RTECS #: BQ9625000

CAS #: 1336-21-6

UPDATE: October 1997 MW: 35.06 MF: H5NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Ammonia aqueous
  2. Ammonia water 29%
  1. Aqua ammonia


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		250 µg severe AJOPAA 29,1363,1946
eye
rabbit 		44 µg severe AROPAW 25,839,1941
eye
rabbit 		1 mg/30S rinse severe TXCYAC 23,281,1982


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 10 mg/disc (-enzymatic activation step) ANYAA9 76,475,1958


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published lethal concentration: 5,000 ppm N/R 34ZIAG -,95,1969
inhalation
human 		lowest published toxic concentration: 408 ppm Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Acute pulmonary edema 		JISMAB 61,271,1971
intravenous
mouse 		lethal dose (50 percent kill): 91 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation 		JCINAO 37,497,1958
intravenous
rabbit 		lowest published lethal dose: 10 mg/kg N/R HBAMAK 4,1289,1935
oral
cat 		lowest published lethal dose: 750 mg/kg N/R HBAMAK 4,1289,1935
oral
human 		lowest published lethal dose: 43 mg/kg N/R 34ZIAG -,95,1969
oral
rat 		lethal dose (50 percent kill): 350 mg/kg Gastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		JIHTAB 23,259,1941
parenteral
frog 		lowest published lethal dose: 2,500 mg/kg N/R 85IXA4 -,688,1948
subcutaneous
mouse 		lowest published lethal dose: 160 mg/kg N/R 85IXA4 -,688,1948
subcutaneous
rabbit 		lowest published lethal dose: 200 mg/kg N/R 85IXA4 -,688,1948


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 06145;
Number of Industries 297;
Total Number of Facilities 85,664;
Number of Occupations 161;
Total Number of Employees Exposed 735,671
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 06145;
Number of Industries 326;
Total Number of Facilities 66,188;
Number of Occupations 188;
Total Number of Employees Exposed 1,022,551;
Total Number of Female Employees Exposed 379,643


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as reagent in chemical analysis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JISMAB Journal of the Iowa State Medical Society. (Des Moines, IA) 1911-1983(?).
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as reagent in chemical analysis

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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