The Registry of Toxic Effects of Chemical Substances

Aniline, 2,6 - dichloro - 4 - nitro -

RTECS #: BX2975000

CAS #: 99-30-9

UPDATE: August 2003 MW: 207.02 MF: C6H4Cl2N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. AL - 50
  2. Allisan
  3. Benzenamine, 2,6 - dichloro - 4 - nitro - (9CI)
  4. Bortran
  5. Botran
  6. Botran 45W
  7. CDNA
  8. CNA
  9. DCNA
  1. DCNA (fungicide)
  2. 2,6 - Dichlor - 4 - nitroanilin (Czech)
  3. 2,6 - Dichloro - 4 - nitroaniline
  4. 2,6 - Dichloro - 4 - nitrobenzenamine
  5. Ditranil
  6. 4 - Nitroaniline, 2,6 - dichloro -
  7. RD - 6584
  8. Resisan
  9. U - 2069


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Aspergillus nidulans 14 µmol/L (-enzymatic activation step) PHYTAJ 66,217,1976
mutation in microorganisms Salmonella typhimurium 2,500 µg/plate (+enzymatic activation step) SAIGBL 29,34,1987
mutation in microorganisms Salmonella typhimurium 100 µg/plate (-enzymatic activation step) EMMUEG 19(Suppl 21),2,1992
sex chromosome loss and nondisjunction Aspergillus nidulans 38 µmol/L EVHPAZ 31,81,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 80 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >21,600 mg/m3/1 hour N/R PEMNDP 9,265,1991
intravenous
mouse 		lethal dose (50 percent kill): 56 mg/kg N/R CSLNX* NX#03022
oral
duck 		lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,265,1991
oral
guinea pig 		lethal dose (50 percent kill): 1,450 mg/kg N/R PCOC** -,343,1966
oral
mouse 		lethal dose (50 percent kill): 1,500 mg/kg N/R PCOC** -,343,1966
oral
rat 		lethal dose (50 percent kill): 2,400 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		TSCAT* OTS 206512
skin
mouse 		lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,265,1991
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,265,1991
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,500 mg/kg N/R 30ZDA9 -,87,1971
unreported route
mouse 		lethal dose (50 percent kill): 4,490 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Ataxia 		GISAAA 54(11),4,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 54,600 mg/kg/2 year- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 12,314,1968
oral
rat 		lowest published toxic dose: 12 gm/kg/60 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia GISAAA 54(11),4,1989
oral
rat 		lowest published toxic dose: 16 gm/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		GISAAA 54(11),4,1989
oral
rat 		lowest published toxic dose: 109 gm/kg/2 year- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 12,314,1968


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CRTXB2 1(1),93,1971


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,107,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Aspergillus-aneuploidy; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a protective fungicide
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PHYTAJ Phytopathology. (American Phytopathological Soc., 3340 Pilot Knob Rd., St. Paul, MN 55121) V.1- 1911-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a protective fungicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

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