The Registry of Toxic Effects of Chemical Substances

Aniline, N,N - dimethyl -

RTECS #: BX4725000

CAS #: 121-69-7

UPDATE: February 2005 MW: 121.20 MF: C8H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. (Dimethylamino) benzene
  2. Benzenamine, N,N - dimethyl -
  3. Dimethylaniline
  4. Dimethylaniline (ACGIH:OSHA)
  5. Dwumetyloanilina (Polish)
  6. N,N - Dimethylaniline
  1. N,N - Dimethylaniline (OSHA)
  2. N,N - Dimethylbenzenamine
  3. N,N - Dimethylphenylamine
  4. NCI - C56428
  5. NL 63 - 10P
  6. Versneller NL 63/10


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,461,1986
skin
rabbit 		10 mg/24 hour open irritation test mild AIHAAP 23,95,1962
skin
rabbit 		500 mg/24 hour mild 85JCAE -,461,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 83 mg/L EMMUEG 13,60,1989
DNA damage intraperitoneal
mouse 		485 mg/kg EMMUEG 21,349,1993
DNA damage intraperitoneal
rat 		485 mg/kg EMMUEG 21,349,1993
micronucleus test hamster lung 900 µmol/L EMMUEG 21,349,1993
mutation in mammalian somatic cells mouse lymphocyte 20 mg/L NTPTR* NTP-TR-360,1989
sister chromatid exchange hamster ovary 30 mg/L EMMUEG 13,60,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 15,450 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors 		NTPTR* NTP-TR-360,1989
oral
mouse 		lowest published toxic dose: 15,450 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB90-227240/AS
oral
rat 		lowest published toxic dose: 15,450 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors 		NTPTR* NTP-TR-360,1989
oral
rat 		lowest published toxic dose: 15,450 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors 		NTIS** PB90-227240/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 250 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement 		GISAAA 37(4),35,1972
oral
human 		lowest published lethal dose: 50 mg/kg Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes 		NCPBBY Jan/Feb,1969
oral
mouse 		lowest published lethal dose: 350 mg/kg N/R NTPTR* NTP-TR-360,1989
oral
rat 		lethal dose (50 percent kill): 951 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis 		NTIS** OTS0571982
subcutaneous
rat 		lowest published lethal dose: 100 mg/kg N/R 85GMAT -,55,1982
skin
guinea pig 		lethal dose (50 percent kill): >20 mL/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0571982
skin
rabbit 		lethal dose (50 percent kill): 1,770 µL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 10,700 µg/m3/5 hour/17 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GISAAA 37(4),35,1972
inhalation
rat 		lowest published toxic concentration: 300 µg/m3/24 hour/14 week- continuous Behavioral: Muscle contraction or spasticity

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count 		GISAAA 34(3),7,1969
oral
mouse 		lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Blood: Changes in spleen JTEHD6 29,77,1990
oral
mouse 		lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		NTPTR* NTP-TR-360,1989
oral
rat 		lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTEHD6 29,77,1990
oral
rat 		lowest published toxic dose: 16,250 mg/kg/13 week- intermittent Liver: Other changes

Blood: Changes in bone marrow not included in above

Blood: Changes in spleen 		NTPTR* NTP-TR-360,1989
oral
rat 		lowest published toxic dose: 2 gm/kg/2 day- intermittent Behavioral: Food intake (animal)

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0571982
oral
rat 		lowest published toxic dose: 1,100 mg/kg/15 day- intermittent Endocrine: Changes in spleen weight NTIS** OTS0571982
oral
rat 		lowest published toxic dose: 1,545 mg/kg/103 week- intermittent Blood: Leukemia

Tumorigenic: Active as anti-cancer agent 		NTIS** PB90-227240/AS


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin);short term exposure limit 10 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 10 ppm (skin) DTLVS* TLV/BEI,2002
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 57,337,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 57,337,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 57,337,1993
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (25 mg/m3), Skin, Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (25 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 5 ppm (25 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (25 mg/m3)Skin, Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (25 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 40 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (5 mg/m3), short term exposure limit 2 ppm (10 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (25 mg/m3), KZG- week 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 10 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 10 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLANILINE-air 10 hour time-weighted average 5 ppm (Sk);
short term exposure limit 10 ppm (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 26335;
Number of Industries 4;
Total Number of Facilities 100;
Number of Occupations 10;
Total Number of Employees Exposed 2,456
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 26335;
Number of Industries 15;
Total Number of Facilities 1,428;
Number of Occupations 27;
Total Number of Employees Exposed 30,480;
Total Number of Female Employees Exposed 7,448


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate, solvent, emulsifier and laboratory reagent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aromatic, 2002
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-360,1989
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCPBBY National Clearinghouse for Poison Control Centers, Bulletin. (U.S. Department of Health, Education, and Welfare, Washington, DC)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

Used as a chemical intermediate, solvent, emulsifier and laboratory reagent

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 162744-63-0
ALT CAS #: 168153-21-7
ALT CAS #: 171745-67-8
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