The Registry of Toxic Effects of Chemical Substances

Aniline, m - nitro -

RTECS #: BY6825000

CAS #: 99-09-2

UPDATE: July 2000 MW: 138.14 MF: C6H6N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Amarthol Fast Orange R Base
  2. m - Aminonitrobenzene
  3. 1 - Amino - 3 - nitrobenzene
  4. Azobase MNA
  5. Benzenamine, 3 - nitro - (9CI)
  6. C.I. 37030
  7. C.I. Azoic Diazo Component 7
  8. Daito Orange Base R
  9. Devol Orange R
  10. Diazo Fast Orange R
  11. Fast Orange Base R
  12. Fast Orange M Base
  1. Fast Orange MM Base
  2. Fast Orange R Base
  3. Fast Orange R Salt
  4. Hiltonil Fast Orange R Base
  5. Naphtoelan Orange R Base
  6. Nitranilin
  7. m - Nitroaminobenzene
  8. 3 - Nitroaniline
  9. 3 - Nitrobenzenamine
  10. m - Nitrophenylamine
  11. Orange Base IRGA I


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 5 mg/disc MUREAV 170,11,1986
mutation in microorganisms Salmonella typhimurium 500 µg/plate (+enzymatic activation step) IJCMDW 7,277,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
dog 		lowest published lethal dose: 70 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		JIDHAN 2,247,1920
oral
guinea pig 		lethal dose (50 percent kill): 450 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		VKMGA7 6,89,1966
oral
mouse 		lethal dose (50 percent kill): 308 mg/kg N/R AMRL** TR-72-62,1972
oral
quail 		lethal dose (50 percent kill): 562 mg/kg N/R AECTCV 12,355,1983
oral
rat 		lethal dose (50 percent kill): 535 mg/kg N/R AMRL** TR-72-62,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 420 mg/kg/28 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Normocytic anemia 		ESKHA5 (109),72,1991
oral
rat 		lowest published toxic dose: 2,940 mg/kg/3 week- intermittent Blood: Other changes

Blood: Changes in erythrocyte (RBC) count 		VKMGA7 6,89,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - POLAND MAC(time-weighted average) 3 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJCMDW International Journal of Cosmetic Science. (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1979-
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VKMGA7 Voprosy Kommunal'noi Gigieny. Problems of Communal Hygiene. (Kiev, USSR) V.6, 1966. For publisher information, see GNAMAP.

RTECS Compound Description:
   Mutagen

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