The Registry of Toxic Effects of Chemical Substances

p - Anisidine

RTECS #: BZ5450000

CAS #: 104-94-9

UPDATE: November 2004 MW: 123.17 MF: C7H9NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. p - Aminoanisole
  2. 4 - Aminoanisole
  3. 1 - Amino - 4 - methoxybenzene
  4. Aniline, p - methoxy -
  5. 4 - Anisidine
  6. Anisole, p - amino -
  7. Benzenamine, 4 - methoxy - (9CI)
  8. 4 - Methoxy - 1 - aminobenzene
  1. p - Methoxyaniline
  2. 4 - Methoxyaniline
  3. 4 - Methoxybenzenamine
  4. 4 - Methoxybenzeneamine
  5. p - Methoxyphenylamine
  6. p - Anisidine (ACGIH:OSHA)
  7. p - Anisylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 160 mg/L EMMUEG 10(Suppl 10),1,1987
DNA damage mouse lymphocyte 202 µmol/L MUREAV 203,155,1988
DNA damage mouse other cell types 32 mg/L/24 hour (-enzymatic activation step) MUREAV 541,9,2003
DNA inhibition oral
mouse 		200 mg/kg MUREAV 46,305,1977
DNA repair Escherichia coli 39 mmol/L MUREAV 272,145,1992
host-mediated assay mouse
Escherichia coli 		780 mg/kg MUREAV 272,161,1992
mutation in microorganisms mouse lymphocyte 196 µmol/L (+enzymatic activation step) MUTAEX 3,193,1988
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in mammalian somatic cells mouse lymphocyte 392 µmol/L MUTAEX 3,193,1988
sister chromatid exchange hamster ovary 14 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 806 mg/kg N/R JMCMAR 17,900,1974
intraperitoneal
rat 		lethal dose (50 percent kill): 1,400 mg/kg N/R AGGHAR 15,447,1957
oral
mouse 		lethal dose (50 percent kill): 1,410 mg/kg Eye: Other eye effects

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia 		ATDAEI 1,184,1992
oral
rat 		lethal dose (50 percent kill): 1,320 mg/kg N/R TLSMA6 128,14,1979
oral
rabbit 		lethal dose (50 percent kill): 2,900 mg/kg Kidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia

Blood: Other changes 		IMEMDT 27,63,1982
skin
rat 		lethal dose (50 percent kill): 3,200 mg/kg N/R AGGHAR 15,447,1957


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/4 hour/1 year- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Blood: Pigmented or nucleated red blood cells

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 4,91,1962


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 27,63,1982
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.5 mg/m3) (skin) DTLWS* 3,10,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - INDIA time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, Skin, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.5 mg/m3), KZG- week 0.2 ppm (1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.53 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-ANISIDINE-air 10 hour time-weighted average 0.5 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for the production of dyes and pharmaceuticals
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Anisidine, 2514


REFERENCES:

CODEN
REFERENCE
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used for the production of dyes and pharmaceuticals

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen

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