The Registry of Toxic Effects of Chemical Substances

o - Anisidine, 5 - methyl -

RTECS #: BZ6720000

CAS #: 120-71-8

UPDATE: May 2005 MW: 137.20 MF: C8H11NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. m - Amino - p - cresol, methyl ester
  2. 3 - Amino - p - cresol methyl ether
  3. 1 - Amino - 2 - methoxy - 5 - methylbenzene
  4. 3 - Amino - 4 - methoxytoluene
  5. 2 - Amino - 4 - methylanisole
  6. Azoic Red 36
  7. Benzenamine, 2 - methoxy - 5 - methyl - (9CI)
  8. C.I. Azoic Red 83
  9. Cresidine
  1. p - Cresidine
  2. p - Kresidin (Czech)
  3. Krezidine
  4. 2 - Methoxy - 5 - methylaniline
  5. 2 - Methoxy - 5 - methylbenzenamine
  6. 4 - Methoxy - m - toluidine
  7. 4 - Methyl - 2 - aminoanisole
  8. 5 - Methyl - o - anisidine
  9. NCI - C02982


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,721,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,721,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage oral
mouse 		595 mg/kg MUREAV 412,155,1998
mutation in microorganisms Escherichia coli 2 mg/plate (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms Salmonella typhimurium 62,500 ng (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
morphological transform mouse fibroblast 5 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
morphological transform rat embryo 31 µg/plate JJATDK 1,190,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 355 gm/kg/92 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors 		NCITR* NCI-TR-142,1979
oral
mouse 		toxic dose : 1,607 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors 		IMEMDT 27,91,1982
oral
mouse 		toxic dose : 2,961 gm/kg/92 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors 		IMEMDT 27,91,1982
oral
rat 		lowest published toxic dose: 364 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Kidney, Ureter, and Bladder: Bladder tumors 		NCITR* NCI-TR-142,1979
oral
rat 		toxic dose : 182 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Brain and Coverings: Tumors

Kidney, Ureter, and Bladder: Bladder tumors 		NCITR* NCI-TR-142,1979
oral
rat 		toxic dose : 3,640 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors 		IMEMDT 27,91,1982
oral
rat 		toxic dose : 7,280 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors 		IMEMDT 27,91,1982
oral
rat 		toxic dose : 364 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		ANTRD4 1,279,1981
oral
rat 		toxic dose : 437 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		ANTRD4 1,279,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 1,450 mg/kg N/R HURC** -,-,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 27,91,1982
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 27,91,1982
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND Carcinogen, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a dye, pigment and printing ink
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat NCITR* NCI-TR-142,1979
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ANTRD4 Anticancer Research. (5 Argyropoulou St., Kato Patissia, Athens 907, Greece) V.1- 1981-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
HURC** Huntingdon Research Center Reports. (Box 527, Brooklandville, MD 21022)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Used as a dye, pigment and printing ink

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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