The Registry of Toxic Effects of Chemical Substances

Antimony (III) chloride

RTECS #: CC4900000

CAS #: 10025-91-9

UPDATE: November 2004 MW: 228.10 MF: Cl3Sb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Antimoine (trichlorure d') (French)
  2. Antimonio (tricloruro di) (Italian)
  3. Antimonous chloride
  4. Antimontrichlorid (German)
  5. Antimony butter
  6. Antimony chloride (Sb2Cl6)
  7. Antimoontrichlride (Dutch)
  8. Butter of antimony
  1. Chlorid antimonity (Czech)
  2. Chlorure antimonieux (French)
  3. C.I. 77056
  4. Stibine, trichloro -
  5. Antimony trichloride
  6. Trichlorostibine
  7. Trichlorure d'antimoine (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 10 mmol/L MUREAV 77,109,1980
micronucleus test hamster lung 10 µmol/L MUREAV 412,213,1998
sister chromatid exchange hamster lung 2,500 µg/L MUREAV 264,163,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 1,874 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JANREH 10,15,1996
oral
rat 		lowest published toxic dose: 44 mg/kg (1-22 day pregnant/22 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TCMUD8 7,491,1987
oral
rat 		lowest published toxic dose: 4,400 µg/kg (1-22 day pregnant/22 day after birth) Reproductive: Effects on newborn: Delayed effects TCMUD8 7,491,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
man 		lowest published toxic concentration: 73 mg/m3 Behavioral: Anorexia (human)

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes 		BJIMAG 23,318,1966
intraperitoneal
mouse 		lethal dose (50 percent kill): 13 mg/kg N/R 85GMAT -,23,1982
oral
guinea pig 		lethal dose (50 percent kill): 574 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Gastrointestinal: Peritonitis

Gastrointestinal: Necrotic changes 		HYSAAV 29(12),16,1964
oral
rat 		lethal dose (50 percent kill): 525 mg/kg N/R MarJV# 29MAR1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lowest published toxic dose: 2,282 mg/kg/9 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in other cell count (unspecified) 		GISAAA 29(12),16,1964
oral
guinea pig 		lowest published toxic dose: 8,518 mg/kg/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 29(12),16,1964


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Sb)/m3 DTLVS* TLV/BEI,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(Sb)/m3 DTLVS* 3,15,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 0.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Sb)/m3 (total dust), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg(Sb)/m3, 2003
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Sb)/m3, 2B Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg(Sb)/m3, MAC(short term exposure limit) 1.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 0.2 mg(Sb)/m3, short term exposure limit 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Sb)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 mg(Sb)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 mg(Sb)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ANTIMONY-air 10 hour time-weighted average 0.5 mg(Sb)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 07405;
Number of Industries 6;
Total Number of Facilities 125;
Number of Occupations 9;
Total Number of Employees Exposed 1,947
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 07405;
Number of Industries 9;
Total Number of Facilities 344;
Number of Occupations 11;
Total Number of Employees Exposed 22,641;
Total Number of Female Employees Exposed 7,292


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a reagent for CHLORAL, aromatic hydrocarbons, VITAMIN A, and for drug identification
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JANREH Journal of Applied Animal Research. (Garuda Scientific Publications, 151, Janakpuri, Izatnagar, 243122, India) V.1- 1992-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MarJV# Personal Communication from J.V. Marhold, VUOS, 539-18, Pardubice, Czechoslavakia, Mar. 29, 1977
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-

Used as a reagent for CHLORAL, aromatic hydrocarbons, VITAMIN A, and for drug identification

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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