The Registry of Toxic Effects of Chemical Substances

Arsine

RTECS #: CG6475000

CAS #: 7784-42-1

UPDATE: November 2004 MW: 77.95 MF: AsH3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Arsenic hydrid
  2. Arsenic hydride
  3. Arsenowodor (Polish)
  4. Arsenwasserstoff (German)
  5. Arsenic trihydride
  1. Hydrogen arsenide
  2. Arsine (ACGIH:OSHA)
  3. Arseniuretted hydrogen
  4. Arsenous hydride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2.5 ppm (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTPTR* #TER87038


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 150 mg/m3/20 minute N/R HBAMAK 4,1306,1935
inhalation
dog 		lethal concentration (50 percent kill): 350 mg/m3/30 minute N/R NTIS** PB158-508
inhalation
dog 		lethal concentration (50 percent kill): 0.5 mg/m3/15 minute N/R VCVN5* -,87,1993
inhalation
domestic animal 		lethal concentration (50 percent kill): 1 gm/m3/10 minute N/R NTIS** PB158-508
inhalation
frog 		lowest published lethal concentration: 4,500 mg/m3/3 hour Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Altered sleep time (including change in righting reflex)

Cardiac: Other changes 		AEXPBL 80,288,1917
inhalation
human 		lowest published toxic concentration: 3 ppm Blood: Pigmented or nucleated red blood cells

Blood: Other hemolysis with or without anemia 		AMIHAB 21,132,1960
inhalation
human 		lowest published lethal concentration: 25 ppm/30 minute Blood: Other hemolysis with or without anemia

Endocrine: Change in GH 		AEHLAU 19,133,1969
inhalation
human 		lowest published lethal concentration: 300 ppm/5 minute N/R TABIA2 3,231,1933
inhalation
man 		lowest published toxic concentration: 325 µg/m3 Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Hematuria 		AEHLAU 34,224,1979
inhalation
monkey 		lowest published lethal concentration: 600 mg/m3/1 hour N/R HBAMAK 4,1306,1935
inhalation
mouse 		lethal concentration (50 percent kill): 250 mg/m3/10 minute N/R NTIS** PB158-508
inhalation
mouse 		lethal concentration (50 percent kill): 0.5 mg/m3/2 minute N/R VCVN5* -,87,1993
inhalation
mouse 		lethal concentration (50 percent kill): 0.1 mg/m3/15 minute N/R VCVN5* -,87,1993
inhalation
mouse 		lowest published lethal concentration: 0.63 ppm/30 minute N/R TOXID9 72,160,2003
inhalation
mouse 		lowest published lethal concentration: 0.5 ppm/1 hour N/R TOXID9 72,160,2003
inhalation
mouse 		lowest published lethal concentration: 0.13 ppm/4 hour N/R TOXID9 72,160,2003
inhalation
mouse 		lowest published lethal concentration: 0.6 ppm/8 hour N/R TOXID9 72,160,2003
inhalation
rat 		lethal concentration (50 percent kill): 390 mg/m3/10 minute N/R NTIS** PB158-508
inhalation
rat 		lethal concentration (50 percent kill): 0.3 mg/m3/15 minute N/R VCVN5* -,87,1993
inhalation
rabbit 		lethal concentration (50 percent kill): 650 mg/m3/10 minute N/R NTIS** PB158-508
inhalation
rabbit 		lethal concentration (50 percent kill): 0.4 mg/m3/15 minute Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Gastrointestinal: Necrotic changes

Kidney, Ureter, and Bladder: Hematuria 		VCVN5* -,87,1993
intraperitoneal
cat 		lethal dose (50 percent kill): 2 mg/kg N/R BJPCAL 1,287,1946
intraperitoneal
domestic animal 		lethal dose (50 percent kill): 3 mg/kg N/R BJPCAL 1,287,1946
intraperitoneal
mouse 		lethal dose (50 percent kill): 3 mg/kg N/R BJPCAL 1,287,1946
intraperitoneal
rabbit 		lethal dose (50 percent kill): 2,500 µg/kg N/R BJPCAL 1,287,1946


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 2,500 ppm/6 hour/28 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Other changes 		FAATDF 14,776,1990
inhalation
mouse 		lowest published toxic concentration: 5 ppm/6 hour/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified) 		FAATDF 14,776,1990
inhalation
mouse 		lowest published toxic concentration: 500 ppb/12 week- intermittent Endocrine: Changes in spleen weight

Blood: Changes in spleen

Blood: Changes in leukocyte (WBC) count 		TXAPA9 97,173,1989
inhalation
mouse 		lowest published toxic concentration: 2.5 ppm/10 day- intermittent Endocrine: Changes in spleen weight NTPTR* ##TER87038
inhalation
rat 		lowest published toxic concentration: 2,500 ppm/6 hour/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Other changes 		FAATDF 14,776,1990
inhalation
rat 		lowest published toxic concentration: 500 ppm/6 hour/28 day- intermittent Endocrine: Changes in spleen weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		FAATDF 14,776,1990
inhalation
rat 		lowest published toxic concentration: 500 ppm/6 hour/90 day- intermittent Endocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count 		FAATDF 14,776,1990
inhalation
rat 		lowest published toxic concentration: 0.3 mg/m3/24 hour/13 week- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in leukocyte (WBC) count 		VCVN5* -,92,1989
inhalation
rat 		lowest published toxic concentration: 2.5 ppm/10 day- intermittent Endocrine: Changes in spleen weight

Blood: Changes in cell count (unspecified) 		NTPTR* ##TER87038
inhalation
rat 		lowest published toxic concentration: 5 ppm/12 day- intermittent Blood: Other changes NTPTR* ##TER87038
intraperitoneal
mouse 		lowest published toxic dose: 12 mg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BJPCAL 1,287,1946
intraperitoneal
rabbit 		lowest published toxic dose: 5,500 µg/kg/11 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BJPCAL 1,287,1946


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 23,39,1980
TOXICOLOGY REVIEW
NEJMAG 291,1171,1974
TOXICOLOGY REVIEW
AMIHAB 21,132,1960
TOXICOLOGY REVIEW
PTPAD4 1,189,1976
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
JTEHD6 46,399,1995


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 ppm (0.2 mg/m3) DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.05 ppm (0.2 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.05 ppm (0.2 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.05 ppm (0.2 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.05 ppm (0.2 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.05 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.05 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 0.01 ppm (0.03 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 ppm (0.2 mg/m3), VLE 0.2 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.05 mg/m3, short term exposure limit 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.01 ppm (0.032 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.003 ppm (0.01 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.05 ppm (0.5 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.2 mg/m3, MAC(short term exposure limit) 0.6 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 ppm, short term exposure limit 0.1 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.02 ppm (0.05 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.16 mg/m3), KZG- week 0.25 ppm, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.05 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.05 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.05 ppm (0.16 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSINE-air Carcinogen ceiling concentration 0.002 mg/m3/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 07580;
Number of Industries 4;
Total Number of Facilities 55;
Number of Occupations 5;
Total Number of Employees Exposed 586
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 07580;
Number of Industries 5;
Total Number of Facilities 293;
Number of Occupations 11;
Total Number of Employees Exposed 3,933;
Total Number of Female Employees Exposed 1,254


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of semiconductor components and as a poison gas
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 32, 1979, BULLETIN 14, 1976, AND BULLETIN 23, 1978
NIOSH Analytical Method, 1994: Arsine, 6001
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen
OSHA ANALYTICAL METHOD #ID-125G


REFERENCES:

CODEN
REFERENCE
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PTPAD4 Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and Metabolic Inhibitors. (Oxford, UK) V.1-2, 1976-78. For publisher information, see PHTHDT.
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63. Discontinued.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in manufacture of semiconductor components and as a poison gas

NIOSH PROFILE (JEWELRY MANUFACTURING), SRC,

NIOSH PROFILE (PETROCHEMICAL PLANTS), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Human Data

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