The Registry of Toxic Effects of Chemical Substances

Arsenic acid, calcium salt (2:3)

RTECS #: CG0830000

CAS #: 7778-44-1

UPDATE: November 2004 MW: 398.08 MF: As2O8•3Ca


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Arseniate de calcium (French)
  2. Calcium arsenate
  3. Calcium orthoarsenate
  4. Calciumarsenat
  5. Chip - Cal granular
  6. Cucumber dust
  7. Fencal
  1. Kalziumarseniat (German)
  2. Kilmag
  3. Pencal
  4. Spra - cal
  5. Tricalcium arsenate
  6. Tricalciumarsenat (German)
  7. Turf - cal


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratracheal
hamster 		lowest published toxic dose: 120 mg/kg/15 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		CALEDQ 27,99,1985
intratracheal
hamster 		toxic dose : 214 mg/kg/15 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		IJCNAW 40,220,1987
intratracheal
rat 		lowest published toxic dose: 1,600 µg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application 		IJCNAW 24,786,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lethal dose (50 percent kill): 38 mg/kg N/R 85DPAN -,-,1971/1976
oral
mouse 		lethal dose (50 percent kill): 794 mg/kg N/R AMRL** TR-72-62,1972
oral
rat 		lethal dose (50 percent kill): 20 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Dehydration 		AFDOAQ 15,122,1951
oral
rabbit 		lowest published lethal dose: 50 mg/kg N/R JPETAB 39,246,1930
skin
rat 		lethal dose (50 percent kill): 2,400 mg/kg N/R 28ZEAL 5,35,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 24 gm/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		PHRPA6 56,1610,1941


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(As)/m3 DTLVS* TLV/BEI,1997
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 23,39,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMSUDL 7,100,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,39,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,100,1987
TOXICOLOGY REVIEW
85DHAX As,-,1977
TOXICOLOGY REVIEW
TOLED5 133,1,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,160,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 1 mg(As)/m3, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - POLAND time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.03 mg(As)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(As)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(As)/m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an insecticide, pesticide and herbicide
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74.
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as an insecticide, pesticide and herbicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen

ALT CAS #: 1333-25-1
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