The Registry of Toxic Effects of Chemical Substances

Arsenic acid, disodium salt

RTECS #: CG0875000

CAS #: 7778-43-0

UPDATE: November 2004 MW: 185.91 MF: AsHO4•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Disodium arsenate
  2. Disodium arsenic acid
  3. Disodium hydrogen arsenate
  4. Disodium hydrogen orthoarsenate
  1. Disodium monohydrogen arsenate
  2. Sodium acid arsenate
  3. Sodium arsenate, dibasic
  4. Sodium arsenate dibasic, anhydrous


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 80 µmol/L ENMUDM 4,493,1982
cytogenetic analysis hamster embryo 64 µmol/L CRNGDP 6,1421,1985
cytogenetic analysis hamster ovary 1 µmol/L ENMUDM 4,493,1982
cytogenetic analysis human other cell types 50 µmol/L TIVIEQ 5,353,1991
DNA inhibition human other cell types 10 µmol/L AKEDAX 237,819,1970
DNA inhibition human lymphocyte 100 nmol/L ADMFAU 242,343,1972
DNA inhibition intraperitoneal
rat 		45 mg/kg ENVRAL 28,1,1982
DNA repair Bacillus subtilis 50 mmol/L MUREAV 31,185,1975
DNA repair Bacillus subtilis 100 mmol/L MUREAV 77,109,1980
DNA repair Escherichia coli 130 µg/well ENMUDM 3,429,1981
mutation in microorganisms mouse lymphocyte 18 mg/L (+enzymatic activation step) JTEHD6 9,367,1982
morphological transform hamster embryo 2,500 µg/L CNREA8 39,1008,1979
morphological transform mouse embryo 20 µmol/L CRNGDP 8,803,1987
other mutation test systems human lymphocyte 100 nmol/L ADMFAU 242,343,1972
other mutation test systems intraperitoneal
rat 		45 mg/kg ENVRAL 28,1,1982
sister chromatid exchange hamster embryo 10 µmol/L CRNGDP 6,1421,1985
sister chromatid exchange hamster ovary 1 µmol/L ENMUDM 4,493,1982
sister chromatid exchange human lymphocyte 2,500 µg/L MUREAV 119,415,1983
specific locus test parenteral
Drosophila melanogaster 		1,080 µmol/L EMMUEG 25,288,1995
specific locus test oral
Drosophila melanogaster 		10 µmol/L EMMUEG 25,288,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published lethal dose: 34,720 µg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes 		JPETAB 58,454,1936


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 450 mg/kg/90 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS 		BECTA6 50,100,1993


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(As)/m3 DTLVS* TLV/BEI,1997
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(As)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Skin, Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg(As)/m3, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 0.1 ppm, JAN1993
Occupational Exposure Limit - HUNGARY short term exposure limit 0.5 mg(As)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.03 mg(As)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(As)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(As)/m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in dyeing with turkey-red oil and in printing fabrics
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
ADMFAU Archiv fuer Dermatologische Forschung. (Berlin, Ger.) V.240-252, 1971-75. For publisher information, see ADREDL.
AKEDAX Archiv fuer Klinische und Experimentelle Dermatologie. (Berlin, Ger.) V.201-239, 1955-71. For publisher information, see ADMFAU.
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-

Used in dyeing with turkey-red oil and in printing fabrics

RTECS Compound Description:
   Mutagen

ALT CAS #: 55957-14-7
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