The Registry of Toxic Effects of Chemical Substances

Arsenic acid, lead (2+) salt (1:1)

RTECS #: CG0980000

CAS #: 7784-40-9

UPDATE: November 2004 MW: 347.12 MF: AsHO4•Pb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Acid lead arsenate
  2. Acid lead orthoarsenate
  3. Arsenate of lead
  4. Dibasic lead arsenate
  5. Gypsine
  6. Lead acid arsenate
  7. Lead arsenate
  1. Lead arsenate (ACGIH:OSHA)
  2. Lead arsenate (standard)
  3. Lead hydrogenarsenate
  4. Ortho L40 dust
  5. Schultenite
  6. Standard lead arsenate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 128 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature decrease 		GISAAA 51(1),74,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 128 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		VCVN1* -,428,1988
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,285 mg/kg N/R VCVN5* -,89,1993
oral
chicken 		lethal dose (50 percent kill): 450 mg/kg N/R PCOC** -,653,1966
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 10 mg/kg N/R YKYUA6 37,1323,1986
oral
mouse 		lethal dose (50 percent kill): 1,526 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature decrease 		GISAAA 51(1),74,1986
oral
mouse 		lethal dose (50 percent kill): 1,500 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		VCVN1* -,428,1988
oral
mouse 		lethal dose (50 percent kill): 1,526 mg/kg N/R VCVN5* -,89,1993
oral
rat 		lethal dose (50 percent kill): 100 mg/kg N/R PCOC** -,653,1966
oral
rat 		lethal dose (50 percent kill): 3,100 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		VCVN1* -,428,1988
oral
rabbit 		lethal dose (50 percent kill): 100 mg/kg N/R JPIFAN (3),5,1970
skin
rat 		lethal dose (50 percent kill): >2,400 mg/kg N/R TXAPA9 14,515,1969
unreported route
mammal (species unspecified) 		lowest published lethal dose: 10 mg/kg N/R YKYUA6 38,89,1987


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2,420 mg/kg/11 day- intermittent Gastrointestinal: Gastritis

Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Other changes 		VCVN1* -,428,1988
oral
rat 		lowest published toxic dose: 36 gm/kg/2 year- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		PHRPA6 56,1610,1941
oral
rat 		lowest published toxic dose: 2,420 mg/kg/11 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Interstitial nephritis 		GISAAA 51(1),74,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.15 mg/m3 DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 23,39,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 1,40,1972
International Agency for Research on Cancer (IARC) Cancer Review Animal NO EVIDENCE IMEMDT 2,48,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,39,1980
TOXICOLOGY REVIEW
85DHAX As,-,1977
TOXICOLOGY REVIEW
ENVRAL 13,36,1977


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,187,1998
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.15 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LEAD, INORGANIC-air 10 hour time-weighted average <0.1 mg(Pb)/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an insecticide, herbicide and in manufacture of drugs
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as an insecticide, herbicide and in manufacture of drugs

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen

ALT CAS #: 37196-28-4
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