The Registry of Toxic Effects of Chemical Substances

Aziridine, 2 - methyl -

RTECS #: CM8050000

CAS #: 75-55-8

UPDATE: May 2005 MW: 57.11 MF: C3H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Methylazacyclopropane
  2. 2 - Methylaziridine
  3. Methylethylenimine
  4. 2 - Methylethylenimine
  5. Propylene imine
  1. 1,2 - Propyleneimine
  2. Propylene imine (ACGIH:OSHA)
  3. Propylenimine
  4. 1,2 - Propylenimine
  5. RCRA waste number P067


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage hamster lung 300 µmol/L/1 hour BBRCA9 72,732,1976
DNA damage intraperitoneal
mouse 		40 mg/kg MUREAV 467,83,2000
DNA repair Escherichia coli 2 µg/plate JJIND8 62,873,1979
unscheduled DNA synthesis rat liver 10 mg/L MUREAV 97,359,1982
host-mediated assay mouse
Salmonella typhimurium 		355 mg/kg JJIND8 62,911,1979
mutation in microorganisms Escherichia coli 10 µg/plate (+enzymatic activation step) ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms Salmonella typhimurium 3,300 ng/plate (+/-enzymatic activation step) ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms Schizosaccharomyces pombe 5,470 µmol/L (-enzymatic activation step) ADWMAX -,193,1962
micronucleus test intraperitoneal
mouse 		10 mg/kg MUREAV 389,3,1997
gene conversion and mitotic recombination Saccharomyes cerevisiae 100 ppm JJIND8 62,901,1979
morphological transform hamster embryo 1 mg/L JJIND8 67,1303,1981
morphological transform mouse fibroblast 80 µg/L JJIND8 67,1303,1981
morphological transform rat embryo 15 mg/L JJIND8 67,1303,1981
other mutation test systems Escherichia coli 80 nmol/tube MUREAV 147,79,1985
specific locus test oral
Drosophila melanogaster 		1 mmol/L MUREAV 252,305,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,120 mg/kg/28 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors 		NATUAS 230,460,1971
oral
rat 		toxic dose : 3,920 mg/kg/27 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Skin and Appendages: Tumors 		JJIND8 67,75,1981
oral
rat 		toxic dose : 4,129 mg/kg/58 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		JJIND8 67,75,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 500 ppm/1 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		JIHTAB 30,2,1948
inhalation
mouse 		lethal concentration : >2 gm/m3/10 minute N/R NDRC** NDCrc-132,Feb,1942
inhalation
rat 		lowest published lethal concentration: 500 ppm/4 hour N/R JIHTAB 31,343,1949
intraperitoneal
mouse 		lethal dose (50 percent kill): 355 mg/kg N/R JJIND8 62,911,1979
oral
rat 		lethal dose (50 percent kill): 19 mg/kg N/R JIHTAB 30,63,1948
skin
guinea pig 		lethal dose (50 percent kill): 43 mL/kg N/R JIHTAB 30,63,1948


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 9,61,1975
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1497,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 9,61,1975
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1497,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1497,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 ppm (5 mg/m3) (skin) DTLVS* 3,218,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (5 mg/m3), Skin, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Skin, Carcinogen, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 2 ppm (5 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 2 ppm (4.7 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.6 µg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 2 ppm, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (5 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYLENE IMINE-air Carcinogen;
10 hour time-weighted average 2 ppm (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 08390;
Number of Industries 1;
Total Number of Facilities 5;
Number of Occupations 2;
Total Number of Employees Exposed 20


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the modification of latex surface coating resins
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
ADWMAX Abhandlungen der Deutschen Akademie der Wissenschaften zu Berlin, Klasse fuer Medizin. (Berlin, Ger. Dem. Rep.) 1950-68. Discontinued.
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used in the modification of latex surface coating resins

NIOSH PROFILE (INCINERATION), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen

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