The Registry of Toxic Effects of Chemical Substances

Benzaldehyde

RTECS #: CU4375000

CAS #: 100-52-7

UPDATE: February 2005 MW: 106.13 MF: C7H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Almond artificial essential oil
  2. Artificial almond oil
  3. Artificial essential oil of almond
  4. Benzene carbaldehyde
  5. Benzenecarbonal
  1. NCI - C56133
  2. Benzaldehyde FFC
  3. Benzoic aldehyde
  4. Phenylmethanal


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 14,693,1976


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 1 gm/L ESKHA5 (103),64,1985
cytogenetic analysis oral
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis oral
rat 		0.5 ppb EMMUEG 39,69,2002
mutation in mammalian somatic cells mouse lymphocyte 400 mg/L NTPTR* NTP-TR-378,1990
sister chromatid exchange hamster ovary 50 mg/L EMMUEG 10(Suppl 10),1,1987
sister chromatid exchange human lymphocyte 1 mmol/L MUREAV 206,17,1988
specific locus test mouse lymphocyte 400 mg/L EMMUEG 17,196,1991
specific locus test oral
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test oral
rat 		0.5 ppb EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 154 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors 		NTPTR* NTP-TR-378,1990
oral
mouse 		lowest published toxic dose: 206,000 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB90-253782/AS
oral
mouse 		lowest published toxic dose: 154,500 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB90-253782/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 0.15 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,396,1984
inhalation
mouse 		lethal concentration : >500 mg/m3 Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes 		GTPZAB 18(11),40,1974
inhalation
rat 		lethal concentration : >500 mg/m3 Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes 		GTPZAB 18(11),40,1974
intraperitoneal
mouse 		lethal dose (50 percent kill): 9 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes 		EJTXAZ 9,99,1976
oral
guinea pig 		lethal dose (50 percent kill): 1 gm/kg Behavioral: Tremor

Gastrointestinal: Ulceration or bleeding from small intestine

Kidney, Ureter, and Bladder: Urine volume increased 		FCTXAV 2,327,1964
oral
human 		lowest published lethal dose: 714.3 mg/kg N/R VCVGK* -,396,1984
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 2,020 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse 		lethal dose (50 percent kill): 28 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes 		EJTXAZ 9,99,1976
oral
mouse 		lethal dose (50 percent kill): 2,020 mg/kg N/R VCVGK* -,396,1984
oral
rat 		lethal dose (50 percent kill): 1,300 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma 		FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 2,400 mg/kg N/R VCVGK* -,396,1984
subcutaneous
rat 		lowest published lethal dose: 5 gm/kg Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		AIPTAK 27,163,1922
subcutaneous
rabbit 		lethal dose (50 percent kill): 5 gm/kg N/R FCTXAV 14,693,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 500 ppm/6 hour/14 day- continuous Liver: Changes in liver weight

Blood: Changes in other cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AIHAAP 52,503,1991
inhalation
rat 		lowest published toxic concentration: 26 mg/m3/5 hour/17 week- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 18(11),40,1974
oral
mouse 		lowest published toxic dose: 9,600 mg/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-378,1990
oral
rat 		lowest published toxic dose: 9,600 mg/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-378,1990
oral
rat 		lowest published toxic dose: 52 gm/kg/13 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		NTPTR* NTP-TR-378,1990
oral
rat 		lowest published toxic dose: 78 gm/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-378,1990
oral
rat 		lowest published toxic dose: 600 mg/kg/5 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Multiple effects 		VCVGK* -,396,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,237,1998
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - POLAND time-weighted average 10 mg/m3, short term exposure limit 40 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84494;
Number of Industries 18;
Total Number of Facilities 1,409;
Number of Occupations 43;
Total Number of Employees Exposed 15,976
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84494;
Number of Industries 31;
Total Number of Facilities 3,776;
Number of Occupations 58;
Total Number of Employees Exposed 67,721;
Total Number of Female Employees Exposed 27,021


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in dyes, perfume, and flavor
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Carcinogenesis Studies (gavage);some evidence:mouse NTPTR* NTP-TR-378,1990
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse
NCI Carcinogenesis Studies (gavage);no evidence:rat


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in dyes, perfume, and flavor

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Human Data
   Primary Irritant

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