The Registry of Toxic Effects of Chemical Substances

Benzamide, 2,6 - dichlorothio -

RTECS #: CV3850000

CAS #: 1918-13-4

UPDATE: December 1997 MW: 206.09 MF: C7H5Cl2NS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Benzenecarbothioamide, 2,6 - dichloro - (9CI)
  2. Chlorothiamide
  3. Chlorthiamid
  4. Chlorthiamide
  5. Chlorthioamide
  6. Chlortiamid
  7. DCBN
  1. 2,6 - Dichlorobenzenecarbothioamide
  2. 2,6 - Dichlorothiobenzamide
  3. 2,6 - Dichlor - thiobenzamid (German)
  4. Prefix
  5. SD 7961
  6. WL - 5792


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
mouse 		500 mg/kg CYGEDX 14(6),38,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 242 mg/kg Behavioral: Somnolence (general depressed activity) ATXKA8 23,42,1967
oral
chicken 		lethal dose (50 percent kill): >1 gm/kg N/R ATXKA8 23,42,1967
oral
dog 		lethal dose (50 percent kill): >1 gm/kg Gastrointestinal: Nausea or vomiting ATXKA8 23,42,1967
oral
domestic animal 		lowest published lethal dose: 125 mg/kg Behavioral: Sleep ATXKA8 23,42,1967
oral
mouse 		lethal dose (50 percent kill): 500 mg/kg Behavioral: Sleep ATXKA8 23,42,1967
oral
rat 		lethal dose (50 percent kill): 757 mg/kg N/R ATXKA8 23,42,1967
oral
rabbit 		lethal dose (50 percent kill): 300 mg/kg Behavioral: Somnolence (general depressed activity) ATXKA8 23,42,1967
skin
rat 		lethal dose (50 percent kill): >1 gm/kg Behavioral: General anesthetic ATXKA8 23,42,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 16,800 mg/kg/4 week- continuous Liver: Changes in liver weight

Blood: Changes in bone marrow not included in above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		ATXKA8 23,42,1967
oral
rat 		lowest published toxic dose: 173 mg/kg/13 week- continuous Liver: Changes in liver weight ATXKA8 23,42,1967
oral
rabbit 		lowest published toxic dose: 3,150 mg/kg/21 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain ATXKA8 23,42,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion


REFERENCES:

CODEN
REFERENCE
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-

Used for total weed control on industrial sites, car parks, roadsides, railways, etc.

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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