The Registry of Toxic Effects of Chemical Substances

Benzenamine, 4,4' - methylenebis (2 - chloro -

RTECS #: CY1050000

CAS #: 101-14-4

UPDATE: May 2005 MW: 267.17 MF: C13H12Cl2N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 3,3' - Dichlor - 4,4' - diaminodiphenylmethan (German)
  2. 3,3' - Dichloro - 4,4' - diaminodifenilmetano (Italian)
  3. 3,3' - Dichloro - 4,4' - diaminodiphenylmethane
  4. 4,4' - Diamino - 3,3' - dichlorodiphenylmethane
  5. 4,4' - Methylene bis (2 - chloroaniline)
  6. 4,4' - Methylene bis (2 - chloroaniline) (ACGIH)
  7. 4,4' - Methylene (bis) - chloroaniline
  8. 4,4' - Methylenebis (2 - chloroaniline)
  9. 4,4' - Methylenebis (o - chloroaniline)
  10. 4,4' - Methylenebis - 2 - chlorobenzenamine
  11. 4,4 - Metilene - bis - O - cloroanilina (Italian)
  12. Aniline, 4,4' - methylenebis (2 - chloro -
  13. Bis amine
  14. Bis (3 - chloro - 4 - aminophenyl) methane
  15. Bis (4 - amino - 3 - chlorophenyl) methane
  16. Bis - amine A
  17. Bisamine S
  18. CL - Mda
  19. Cuamine M
  1. Cuamine MT
  2. Curalin M
  3. Curene 442
  4. Cyanaset
  5. Dacpm
  6. Di ( - 4 - amino - 3 - chlorophenyl) methane
  7. Di - (4 - amino - 3 - clorofenil) metano (Italian)
  8. Diamet Kh
  9. LD 813
  10. MBOCA
  11. MOCA
  12. Mboca
  13. Methylene 4,4' - bis (o - chloroaniline)
  14. Methylene - bis - orthochloroaniline
  15. Millionate M
  16. Quodorole
  17. RCRA waste number U158
  18. p,p' - Methylenebis (alpha - chloroaniline)
  19. p,p' - Methylenebis (o - chloroaniline)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage Bacillus subtilis 1 mg/disc PMRSDJ 1,175,1981
DNA damage oral
mouse 		600 mg/kg MUREAV 440,1,1999
DNA repair Escherichia coli 500 mg/L PMRSDJ 1,195,1981
unscheduled DNA synthesis hamster liver 10 µmol/L TXAPA9 58,231,1981
unscheduled DNA synthesis mouse liver 10 µmol/L TXAPA9 58,231,1981
unscheduled DNA synthesis rat liver 10 µmol/L MUREAV 204,683,1988
unscheduled DNA synthesis rabbit liver 10 µmol/L CNREA8 43,3120,1983
mutation in microorganisms Escherichia coli 100 µg/plate (+enzymatic activation step) PMRSDJ 1,387,1981
mutation in microorganisms mouse lymphocyte 5 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) PMRSDJ 1,261,1981
mutation in microorganisms Salmonella typhimurium 33 µg/plate (-enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 100 mg/L/72 hour (+enzymatic activation step) MUREAV 558,181,2004
micronucleus test intraperitoneal
mouse 		6,400 µg/kg PMRSDJ 1,686,1981
gene conversion and mitotic recombination Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,491,1981
morphological transform hamster embryo 2,500 µg/L AETODY 1,241,1980
morphological transform hamster kidney 80 µg/L BJCAAI 37,873,1978
morphological transform mouse fibroblast 10 µg/L JJIND8 67,1303,1981
morphological transform rat embryo 1 mg/L JJIND8 67,1303,1981
phage inhibition capacity Escherichia coli 1 gm/L PMRSDJ 1,224,1981
sister chromatid exchange hamster ovary 500 µg/L ENMUDM 7,1,1985
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 50 mg/L PMRSDJ 1,468,1981
specific locus test oral
Drosophila melanogaster 		5 mmol/L/48 hour- continuous MUREAV 211,279,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 4,050 mg/kg/77 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		JEPTDQ 2(1),149,1978
oral
rat 		toxic dose : 27 gm/kg/79 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NATWAY 58,578,1971
oral
rat 		toxic dose : 27 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		TXAPA9 31,159,1975
oral
rat 		toxic dose : 11 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		JEPTDQ 2(1),149,1978
oral
rat 		toxic dose : 8,100 mg/kg/77 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Tumors 		JEPTDQ 2(1),149,1978
oral
rat 		toxic dose : 16 gm/kg/77 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		JEPTDQ 2(1),149,1978
oral
rat 		toxic dose : 27 gm/kg/65 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		JEPTDQ 2(1),149,1978
oral
rat 		toxic dose : 34 gm/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		TXAPA9 31,159,1975
oral
rat 		toxic dose : 21 gm/kg/60 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		TXAPA9 31,159,1975
oral
rat 		toxic dose : 24 gm/kg/57 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		TXAPA9 31,159,1975
subcutaneous
rat 		lowest published toxic dose: 25 gm/kg/89 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NATWAY 58,578,1971


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 64 mg/kg N/R PMRSDJ 1,682,1981
oral
guinea pig 		lethal dose (50 percent kill): 400 mg/kg Olfaction: Other olfaction effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis 		GISAAA 55(6),86,1990
oral
mouse 		lethal dose (50 percent kill): 640 mg/kg Olfaction: Other olfaction effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis 		GISAAA 55(6),86,1990
oral
rat 		lethal dose (50 percent kill): 1,140 mg/kg Olfaction: Other olfaction effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis 		GISAAA 55(6),86,1990
subcutaneous
rat 		lethal dose (50 percent kill): >5 gm/kg N/R NATWAY 58,578,1971
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R 85INA8 6,988,1991
unreported route
rat 		lowest published lethal dose: 1 gm/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Cyanosis

Kidney, Ureter, and Bladder: Urine volume increased 		AIHAAP 32,802,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Behavioral: Food intake (animal)

Endocrine: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		WDZAEK 7,30,1993


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 4,65,1974
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 57,271,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,246,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 57,271,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 57,271,1993
TOXICOLOGY REVIEW
AIHAAP 39,496,1978
TOXICOLOGY REVIEW
TOLED5 134,39,2002
TOXICOLOGY REVIEW
MUREAV 5432012003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.02 ppm (0.22 mg/m3), Skin, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.02 ppm (0.22 mg/m3), Skin, Carcinogen, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 0.02 ppm (0.2 mg/m3), short term exposure limit 0.06 ppm, Skin, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 0.02 ppm (0.2 mg/m3), short term exposure limit 0.06 ppm, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.02 ppm (0.22 mg/m3), continuous2 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.005 mg/m3, Skin, 2A Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.02 mg/m3, 2003
Occupational Exposure Limit - SWEDEN Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.02 mg/m3, Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.005 mg/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MOCA-air Carcinogen;
10 hour time-weighted average 0.003 mg/m3 (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83341;
Number of Industries 15;
Total Number of Facilities 376;
Number of Occupations 13;
Total Number of Employees Exposed 2,094
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83341;
Number of Industries 1;
Total Number of Facilities 4;
Number of Occupations 1;
Total Number of Employees Exposed 114


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100186/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a curing agent for isocyanate containing polymers
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: MBOCA in urine, 8302
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #24
OSHA ANALYTICAL METHOD #ID-71


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used as a curing agent for isocyanate containing polymers

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: 29371-14-0
ALT CAS #: 51065-07-7
ALT CAS #: 78642-65-6
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